General Information |
|
Product |
TIRAP3b Antibody |
Description |
Affinity Purified TIRAP3b long form Antibody |
Verified Applications |
ELISA, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Cat, Human, Monkey, Pig |
Immunogen |
Synthetic peptide taken within amino acid region 140-170 on human TIRAP3b long form protein. |
Accession # |
GenBank: AAQ97430.1 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.60-0.65 µg/µl in antibody stabilization buffer |
Form |
Affinity Purified |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
DOT Blot |
1:10,000 |
ELISA |
1:10,000 |
Immunoprecipitation | 1:200 |
Western Blot |
1:250 |
|
|
Uniprot # |
|
Overview |
Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. |
Molecular Function |
Phospholipid binding, signal transducer activity |
Subcellular Location |
Isoform 1: Cytoplasm, Golgi apparatus, Cell membrane, Endoplasmic reticulum, Early endosome membrane, Late endosome membrane. Isoform 2: Endoplasmic reticulum, Early endosome membrane, Late endosome membrane |
Expression |
Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas Isoform 2 is ubiquitously expressed (at lower levels than isoform 1). |
Structure |
Homodimer. Interacts with TLR4, TICAM1, IRF3 and IRF7 in response to LPS. Interacts with IL1R1, IL1RAP, IRAK2, IRAK3 and TRAF6. |
Alternative Nomenclature |
Putative NF-kappa-B-activating protein 502 antibody TICAM2 antibody TIR containing adapter molecule 2 antibody TIR domain containing adaptor protein antibody TIR domain-containing adapter molecule 2 antibody TIRAP3 antibody TIRP antibody Toll-like receptor adaptor protein 3 antibody Toll/interleukin-1 receptor domain-containing protein antibody TRAM antibody TRIF-related adapter molecule antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
TIRAP-FITC | |||
|
TIRAP-BIOTIN | |||
|
P-TIRAP | |||
|
PC-TIRAP | |||
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