General Information |
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Product |
GRK6 Positive Control |
Description |
Western Blot Positive Control G protein-coupled receptor kinase 6 |
Verified Applications |
WB |
Immunogen |
Purified Protein |
Accession # |
NCBI: NP_002073 |
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|
Quantity |
5 Applications |
Volume |
Inquire |
Form |
Western Blot Positive Control |
Storage |
-20⁰C for long term storage |
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Western Blot |
1:2,500-1:5,000 |
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Uniprot # |
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Overview |
Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). |
Molecular Function |
ATP binding beta-adrenergic receptor kinase activity G-protein coupled receptor kinase activity |
Subcellular Location |
Membrane; Lipid-anchor |
Expression |
Widely expressed. |
Structure |
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. |
Alternative Nomenclature |
G protein coupled receptor kinase 6 antibody G protein coupled receptor kinase GRK6 antibody Gprk6 antibody Grk6 antibody |
Protein information supplied by UniProt.
Product | Note | Status | Price | |
---|---|---|---|---|
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GRK6-601AP | |||
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GRK6-BIOTIN | |||
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GRK6-FITC | |||
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P-GRK6 | |||
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