General Information |
|
Product |
PDE9A Antibody |
Description |
Affinity Purified High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform a Antibody |
Verified Applications |
CM, ELISA, ICC/IF, IHC, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic cyclic peptide common to all PDE9A variants. |
Specificity | This antibody does not cross-react with PDE9B protein or any other PDE family members. |
Accession # |
NCBI: NP_002597.1 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.55 µg/µl in antibody stabilization buffer |
Form |
Affinity Purified |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
Confocal Microscopy |
1:100 |
DB |
1:100 |
ELISA |
1:100 |
Immunocytochemistry |
1:100 |
Immunofluorescence |
1:100 |
Immunohistochemistry |
1:100 |
Immunoprecipitation |
1:250 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction. |
Molecular Function |
Hydrolase, 3', 5' -cyclic-GMP phosphodiesterase activity |
Subcellular Location |
Isoform PDE9A1: Cell projection, Cytoplasm, Golgi Apparatus, Endoplasmic reticulum, Isoform PDE9A2: Cell projection, Cytoplasm, Isoform PDE9A3: Cytoplasm, Endoplasmic Reticulum, Isoform PDE9A17: Cytoplasm, Endoplasmic reticulum |
Expression |
Expressed in all tissues examined (testis, brain, small intestine, skeletal muscle, heart, lung, thymus, spleen, placenta, kidney, liver, pancreas, ovary and prostate) except blood. Highest levels in brain, heart, kidney, spleen, prostate and colon. Isoform PDE9A12 is found in prostate. |
Alternative Nomenclature |
FLJ90181 antibody HSPDE9A2 antibody PDE 9A antibody Pde9a antibody Phosphodiesterase 9A antibody phosphodiesterase PDE9A21 antibody |
Protein information supplied by UniProt
Fabgennix PDE9A Antibody has been used in 5 Publications |
|
Dhingra, Anuradha, et al. "PDE9A is expressed in the inner retina and contributes to the normal shape of the photopic ERG waveform." Frontiers in molecular neuroscience 7 (2014). PMID25018695
|
Immunofluorescence, Western Blot; Mouse |
Nagasaki, Shuji, et al. "Phosphodiesterase Type 9 (PDE9) In The Human Lower Urinary Tract: An Immunohistochemical Study."BJU International 109.6 (2012): 934-940. PMID21736695
|
Immunohistochemistry, Western Blot; Human |
Kruse, Lars S., et al. "PDE9A, PDE10A, and PDE11A expression in Rat trigeminovascular pain signalling system." Brain research 1281 (2009): 25-34. PMID19445908
|
Immunohistochemistry, Immunodepletion, Western Blot; Rat |
Almeida, Camila Bononi, et al. "High Expression Of The Cgmp-Specific Phosphodiesterase, PDE9A, In Sickle Cell Disease (SCD) And The Effects Of Its Inhibition In Erythroid Cells And SCD Neutrophils." British Journal Of Haematology 142.5 (2008): 836-844. PMID18564357
|
Western Blot; Human |
Baxendale, Rhona W., and Lynn R. Fraser. "Mammalian sperm phosphodiesterases and their involvement in receptor‐mediated cell signaling important for capacitation." Molecular reproduction and development 71.4 (2005): 495-508. PMID15856425
|
Immunofluorescence, Western Blot; Mouse |
Publishing research using PD9A-101AP? Please let us know, we can cite the reference in this datasheet.
To view the Specification Sheet for PDE9A Antibody, please click the link below:
Product | Note | Status | Price | |
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PD9A-FITC | |||
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PD9A-BIOTIN | |||
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P-PD9A | |||
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PC-PD9A | |||
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