General Information |
|
Product |
Parkin Antibody BIOTIN-Conjugated |
Verified Applications |
ELISA, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human |
Immunogen |
Synthetic peptide taken within amino acid region 390-440 on human Parkin protein. |
Accession # |
GenBank: BAA25751.1 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.55.75 µg/µl in antibody stabilization buffer |
Form |
BIOTIN-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
DB |
1:10,000 |
ELISA |
1:10,000 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Acts within a multiprotein E3 ubiquitin ligase complex, by catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. It also participates in the removal and/or detoxification of proteins that are abnormally folded or damaged. |
Molecular Function |
Ligase, Chaperone binding, Protein kinase binding |
Subcellular Location |
Cytoplasm, Nucleus, Endoplasmic reticulum, Mitochondrion |
Expression |
Expressed highly in the brain, and is also expressed in the heart, testis and skeletal muscle. Expression is down-regulated or absent in tumor biopsies and in the brain of PARK2 patients. |
Structure |
Forms E3 ubiquitin ligase complex with UBE2L3 or UBE2L6. Binds to C2A and C2B domains of SYTqq and interacts and regulates the turnovers of SEPT5. |
Alternative Nomenclature |
AR JP antibody E3 ubiquitin ligase antibody FRA6E antibody LPRS 2 antibody PARK 2 antibody Parkin 2 antibody Parkinson disease (autosomal recessive juvenile) 2 antibody Parkinson protein 2, E3 ubiquitin protein ligase (parkin) antibody PDJ antibody PRKN 2 antibody Ubiquitin E3 ligase PRKN antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
P-PARK | |||
|
PARK-101AP | |||
|
PARK-FITC | |||
|
PC-PARK | |||
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