PDE11A4 Antibody FITC

General Information

Product

PDE11A4 Antibody FITC-Conjugated

Description

FITC-Conjugated Phosphodiesterase 11A4 Antibody

Verified Applications

ELISA, IMM, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide unique to PDE11A4 variant

Accession #

GenBank: BAB62712.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.70-0.75 µg/µl in antibody stabilization buffer

Form

FITC-Conjugated

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Uniprot #

Q9HCR9

Overview

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.

Molecular Function

Hydrolase, 3', 5'-cyclic-GMP phosphodiesterase activity, cGMP binding

Subcellular Location

Cytoplasm

Expression

Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is expressed i

Alternative Nomenclature

cGMP phosphodiesterase 11A antibody

Pde11a antibody

Pde11A2 antibody

Pde11A3 antibody

PDE11A4 antibody

PPNAD2 antibody