General Information |
|
Product |
Phospho-JAK2 Antibody BIOTIN |
Description |
BIOTIN-Conjugated Phosphorylated Tyrosine-protein kinase JAK2 Antibody |
Verified Applications |
ELISA, IHC, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic peptide taken within amino acid region 980-1030 on human JAK2 protein. Phosphorylated 1008 & 1009 tyrosine residues. |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.5 µg/µl in antibody stabilization buffer |
Immunoglobulin |
IgG |
Modification | Phosphorylated tyrosine 1008 & 1009. |
Form |
BIOTIN-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
ELISA |
1:10,000 |
Immunohistochemistry | 1:50-1:100 |
Immunoprecipitation |
1:150 |
Western Blot |
1:500 |
|
|
Uniprot # |
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Overview |
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins (PubMed:7615558). Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins (PubMed:9618263). Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. |
Molecular Function |
Adaptive immunity, Immunity, Innate immunity |
Subcellular Location |
Endomembrane system; Peripheral membrane protein; Cytoplasm; Nucleus |
Expression |
Ubiquitously expressed throughout most tissues. |
Structure |
Possesses 2 protein kinase domains. The second one probably contains the catalytic domain, while the presence of slight differences suggest a different role for protein kinase 1. |
Alternative Nomenclature |
JAK 2 Janus Activating Kinase 2 Janus kinase 2 (a protein tyrosine kinase) Janus kinase 2 JTK 10 THCYT3 Tyrosine protein kinase JAK2 |
Protein information supplied by UniProt
FabGennix Phospho-JAK2 Antibody has been used in 1 Publication |
|
Lee, Chia-Huei, et al. "Novel STAT3 Inhibitor LDOC1 Targets Phospho-JAK2 for Degradation by Interacting with LNX1 and Regulates the Aggressiveness of Lung Cancer." Cancers 11.1 (2019): 63.
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Cell labeling, Western Blot; Human, Mouse |
Publishing research using PJAK2-240AP? Please let us know, we can cite the reference in this datasheet.
Product | Note | Status | Price | |
---|---|---|---|---|
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P-PJAK2 | |||
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PJAK2-101AP | |||
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PJAK2-FITC | |||
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PC-PJAK2 | |||
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