General Information |
|
Product |
Phospho-p27 KIP1 Antibody BIOTIN |
Description |
BIOTIN-Conjugated Phosphorylated Cyclin-dependent kinase inhibitor p27kip1 Antibody Extreme C-epitope |
Verified Applications |
ELISA, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Chicken, Human, Monkey, Mouse, Rat |
Immunogen |
Synthetic peptide taken within amino acid region 148-198 on human Cyclin-dependent kinase inhibitor 1 (p27, KIP1) protein. |
Accession # |
GenBank: AAH01971.1 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.50-0.75 µg/µl in antibody stabilization buffer |
Form |
BIOTIN-Conjugated |
Clonality |
Polyclonal |
Determinant |
Extreme C-epitope |
Storage |
-20⁰C for long term storage |
|
|
DB |
1:10,000 |
ELISA |
1:10,000 |
Immunohistochemistry | 1:50-1:150 |
Immunoprecipitation |
1:150 |
Western Blot |
1:250 |
|
|
Uniprot # |
|
Overview |
Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. |
Molecular Function |
Cyclin-dependent protein serine/threonine kinase inhibitor activity, kinase activity |
Subcellular Location |
Nucleus |
Expression |
Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney. |
Structure |
Forms a ternary complex with CCNE1/CDK2/CDKN1B. Interacts directly with CCNE1; the interaction is inhibited by CDK2-dependent phosphorylation on Thr-187. Interacts with COPS5, subunit of the COP9 signalosome complex. |
Alternative Nomenclature |
AA408329 antibody AI843786 antibody CDKN 1B antibody CDKN 4 antibody Cyclin Dependent Kinase Inhibitor 1B antibody Cyclin dependent kinase inhibitor p27 antibody KIP 1 antibody MEN1B antibody MEN4 antibody p27 antibody p27 Kip1 antibody P27-like cyclin-dependent kinase inhibitor antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
P-PKIP.180 | |||
|
PKIP-180AP | |||
|
PKIP.180-FITC | |||
|
PC-PKIP | |||
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