General Information |
|
Product |
p63 Antibody FITC-Conjugated |
Description |
FITC-Conjugated Tumor protein 63 isoform 6 Antibody |
Verified Applications |
ELISA, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic peptide taken within amino acid region 1-100 on human p63 protein. |
Accession # |
NCBI: NP_001108454 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.59-0.63 µg/µl in antibody stabilization buffer |
Form |
FITC-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
DB |
1:10,000 |
ELISA |
1:10,000 |
Immunoprecipitation |
1:200 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. |
Molecular Function |
Activator, Developmental protein, chromatin binding |
Subcellular Location |
Nucleus |
Expression |
Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues. |
Structure |
Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity. Isoforms Alpha and Gamma interact with HIPK2. Interacts with SSRP1, leading to stimulate coactivator activity. Isoform 1 and isoform 2 interact with WWP1. Interacts with PDS5A. Isoform 5 (via activation domain) interacts with NOC2L. |
Alternative Nomenclature |
AIS antibody Amplified in squamous cell carcinoma antibody B(p51A) antibody B(p51B) antibody Chronic ulcerative stomatitis protein antibody CUSP antibody DN p63 alpha 1 antibody EEC3 antibody Keratinocyte transcription factor antibody KET antibody LMS antibody MGC115972 antibody MGC192897 antibody NBP antibody OFC8 antibody p40 antibody p51 antibody P51/P63 antibody p53CP antibody p63 antibody P73 antibody p73H antibody p73L antibody RHS antibody SHFM4 antibody TAp63alpha antibody TP53CP antibody TP53L antibody TP63 antibody TP73 antibody Transformation related protein 63 antibody Trp53rp1 antibody Trp63 antibody Tumor protein 63 antibody Tumor protein p53-competing protein antibody Tumor protein p63 deltaN isoform delta antibody Tumor protein p73 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
P63-101AP | |||
|
P-P63 | |||
|
P63-BIOTIN | |||
|
PC-P63 | |||
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