General Information

Product

PCSK9 Antibody

Description

Affinity Purified Proprotein convertase subtilisin/kexin type 9 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 30-60 on the NARC1 protein.

Accession #

NCBI:  NP_705793.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.85-1.25 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Western Blot

1:500

Protein

Uniprot #

Q80W65

Overview

Crucial player in the regulation of plasma cholesterol homeostasis

Molecular Function

Hydrolase, Protease, Serine protease

Subcellular Location

Cytoplasm, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Secreted

Expression

Hepatocytes, kidney mesenchymal cells, intestinal ileum, colon epithelia and embryonic brain telencephalon neurons.

Structure

Monomer. Can self-associate to form dimers and higher multimers,Belongs to the peptidase S8 family

Alternative Nomenclature

Convertase subtilisin/kexin type 9 preproprotein antibody

FH3 antibody

HCHOLA3 antibody

LDLCQ1 antibody

NARC 1 antibody

PC 9 antibody

PCSK9 antibody

PSEC0052 antibody

General Information

Product

Niemann Pick C1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1228-1278 on human Niemann-Pick C1 protein.

Accession #

NCBI:  NP_000262.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:4,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

O15118

Overview

Intracellular cholesterol transporter plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment.

Molecular Function

Receptor activity

Subcellular Location

Endosome, Lysosome, Membrane

Expression

Adrenal gland; Cerebral cortex; lung; placenta; lymph node

Structure

Belongs to the patched family.

Alternative Nomenclature

Niemann Pick C1 antibody

Niemann Pick C1 protein precursor antibody

Niemann Pick disease, type C1 antibody

NPC antibody

NPC1 antibody

General Information

Product

NPY2R Antibody

Description

Affinity Purified Neuropeptide Y receptor Y2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 300-381 on human NPY2R protein.

Accession #

GenBank: AAO92062.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DOT Blot

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P49146

Overview

Receptor for neuropeptide Y and peptide YY

Molecular Function

G-protein coupled receptor, Receptor, Transducer

Subcellular Location

Cell membrane, Membrane

Expression

High levels in amygdala, corpus callosum, hippocampus and subthalamic nucleus. Also detectable in caudate nucleus, hypothalamus and substantia nigra.

Structure

Belongs to the G-protein coupled receptor 1 family

Alternative Nomenclature

Neuropeptide Y Receptor Type 2 antibody

NPY2R antibody

NPYY2 Receptor antibody

Y2 receptor antibody

General Information

Product

NPY5R Antibody Affinity Purified

Description

Affinity Purified Neuropeptide Y receptor type 5 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on NPY5R protein.

Accession #

NCBI: NP_006165.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q15761

Overview

Receptor for neuropeptide Y and peptide YY,associated with food intake. Could be involved in feeding disorders.

Molecular Function

G-protein coupled receptor, Receptor, Transducer

Subcellular Location

Cell membrane, Membrane

Expression

Brain; hypothalamus.

Structure

Belongs to the G-protein coupled receptor 1 family

Alternative Nomenclature

Neuropeptide Y receptor type 5 antibody

NPY 5R antibody

NPYY5 antibody

NPYY5-R antibody

Y5 receptor antibody

General Information

Product

KAT13C / NCOA2 Antibody Affinity Purified

Description

Affinity Purified Nuclear receptor coactivator 2 isoform b Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid 1375-1425 on rat NuCR2/GRIP-1/SRC-2 protein.

Accession #

NCBI:  NP_001071163.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.70-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Alternative Nomenclature

bHLHe75 antibody

Class E basic helix-loop-helix protein 75 antibody

glucocorticoid receptor interacting protein 1 antibody

GRIP 1 antibody

hTIF2 antibody

MED1 antibody

MGC138808 antibody

NCoA 2 antibody

Oncogene FGR antibody

p160 antibody

SRC 2 antibody

TIF2 antibody

General Information

Product

Orexin A Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1-50 on ORXN protein.

Accession #

NCBI: NP_034540

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Dot blot

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O55241

Overview

Is a portion of a protein complex (ribonuclease P) that creates mature tRNA molecues through the cleavage of their 5' ends.

Molecular Function

ribonuclease P activity, Endonuclease, Hydrolase, Nuclease

Subcellular Location

Cytoplasm

Structure

Contains a catalytic RNA component and at least 4 to 5 protein subunits.

Alternative Nomenclature

HCRT 1 antibody

HCRT antibody

HCRT2 antibody

Hypocretin 1 antibody

Hypocretin 2 antibody

Hypocretin antibody

Hypocretin neuropeptide precursor antibody

NRCLP1 antibody

Orexin A antibody

Orexin antibody

Orexin B antibody

OX antibody

PPORX antibody

PPOX antibody

PREPROOREXIN antibody

General Information

Product

PINK1 Antibody

Description

Affinity Purified Serine/Threonine-protein kinase PINK1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on human PINK1 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9BXM7

Overview

During cellular stress it serves to protect against mitochondrial dysfunction through the phosphorylation of mitochondrial proteins. Uses selective autophagy to clear mitochondria that has been damaged.

Molecular Function

Kinase, Serine/threonine-protein kinase, Transferase

Subcellular Location

Mitochondrion outer membrane; Single-pass membrane protein, Cytoplasm

Expression

Expression is detected at high levels in the heart, skeletal muscles and testis.  Expression is detected at lower levels in the brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine.

Structure

Interacts with PARK2 and FBXO7

Alternative Nomenclature

BRPK antibody

FLJ27236 antibody

mitochondrial antibody

PARK 6 antibody

Phosphatase and Tensin Homolog antibody

PINK 1 antibody

Protein kinase BRPK antibody

PTEN induced putative kinase 1 antibody

Serine/threonine-protein kinase PINK1 antibody

General Information

Product

Phospho-PDE5A Antibody

Description

Affinity Purified Phosphorylated Phosphodiesterase 5A Antibody

Verified Applications

ELISA, ICC, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Mouse, Pig, Rat, Sheep

Immunogen

Synthetic peptide common to all PDE5A variants taken within amino acid region 120-170 on human PDE5A protein. Phosphoryalted 

Accession #

GenBank: EAX05277.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

1.0-1.25 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:100

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

UPI0000EE2B22

Overview

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.

Molecular Function

Hydrolase, 3',5'-cyclic-GMP phosphodiesterase activity, cGMP binding

Subcellular Location

cytosol

Expression

Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a much lesser extent, in brain, liver and lung.

Alternative Nomenclature

5''-cyclic phosphodiesterase antibody

CGB PDE antibody

cGMP binding cGMP specific 3' 5' cyclic nucleotide phosphodiesterase antibody

cGMP binding/cGMP specific phosphodiesterase antibody

cGMP specific phosphodiesterase type 5A antibody

CN5A antibody

CN5N antibody

PDE 5 antibody

PDE 5A antibody

PDE5A1 antibody

Phosphodiesterase 5A antibody

Phosphodiesterase 5A cGMP specific antibody

Phosphodiesterase isozyme 5 antibody

General Information

Product

RPE65 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on mouse RPE65 protein.

Accession #

GenBank: AAL01119.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.51-0.63 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Western Blot

1:500

Protein

Uniprot #

Q91ZQ5

Overview

Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester.

Molecular Function

Hydrolase, Isomerase

Subcellular Location

Cytoplasm, Cell membrane; Lipid anchor, Microsome membrane

Expression

Retinal pigment epithelium  specific

Structure

Interacts with MYO7A; this mediates light-dependent intracellular transport of RPE65.

Alternative Nomenclature

All-trans-retinyl-palmitate hydrolase antibody

LCA 2 antibody

Leber congenital amaurosis antibody

p63 antibody

rd 12 antibody

Retinal pigment epithelium specific 61 kDa protein antibody

Retinal pigment epithelium specific 65 kDa protein antibody

retinitis pigmentosa 20 antibody

Retinoid isomerohydrolase antibody

RP20 antibody

General Information

Product

ARTS Antibody Affinity Purified

Description

Affinity Purified Septin-4 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 400-450 on SEPT4 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68-075 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O43236

Overview

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli.

Molecular Function

GTPase activity, structural molecule activity, GTP binding

Subcellular Location

Cytoplasm, cytoskeleton. (Note: In platelets, found in areas surrounding alpha-granules)

Expression

Widely expressed in adult and fetal tissues with highest expression in adult brain (at protein level), heart, liver and adrenal gland and fetal heart, kidney, liver and lung. Also expressed in colorectal cancers and malignant melanomas. Expressed in plate

Alternative Nomenclature

Apoptosis Related Protein TGFb Signalling antibody

ARTS antibody

Bradeion beta antibody

Brain protein H5 antibody

CE5B3 antibody

CE5B3 beta antibody

cell division control-related protein 2 antibody

cerebral protein 7 antibody

H5 antibody

hCDCREL-2 antibody

Hucep 7 antibody

MART antibody

Peanut-like protein 2 antibody

PNUTL2 antibody

SEP4 antibody

SEPT4 antibody

Septin-4 antibody