General Information
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Product
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SHC Peptide
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Verified Applications
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Immunocompetition, Immunodepletion
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Peptide Description
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Synthetic peptide taken within amino acid region 425-474 on mouse ShcA protein.
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Accession #
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NCBI: 1589716
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol |
Protein
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Uniprot #
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Q61120
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Overview
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Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.
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Molecular Function
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Angiogenesis, Growth regulation
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Subcellular Location
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Cytoplasm
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Expression
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Widely expressed. Expressed in neural stem cells but absent in mature neurons.
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Structure
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Interacts with the NPXY motif of tyrosine-phosphorylated IGF1R and INSR in vitro via the PID domain. Once activated, binds to GRB2. Interacts with tyrosine-phosphorylated CD3T and DDR2. Interacts with N-terminal region of APS. Interacts with phosphorylated LRP1 and IRS4.Interacts with INPP5D/SHIP1 and INPPL1/SHIP2. Interacts with TRIM31. Interacts with PTPN6/SHP (tyrosine phosphorylated). Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTT. Interacts with ALK, GAB2, GRB7 and KIT. Interacts with FLT4 (tyrosine-phosphorylated). Interacts with EPHB1 and GRB2; activates the MAPK/ERK cascade to regulate cell migration. Interacts with PDGFRB (tyrosine-phosphorylated). Interacts with ERBB4. Interacts with TEK/TIE2 (tyrosine-phosphorylated). Interacts with Trk receptors NTRK1, NTRK2, and NTRK3; in a phosphotyrosine-dependent manner. Interacts with PTK2/FAK1.
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Alternative Nomenclature
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p46 antibody
p52 antibody
p66 antibody
SH2 domain protein C1 antibody
Shc antibody
SHC-transforming protein 1 antibody
SHC-transforming protein 3 antibody
SHC-transforming protein A antibody
SHC1 antibody
SHCA antibody
Src homology 2 domain containing transforming protein C1 antibody
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