General Information
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Product
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PTBP1 Peptide
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Description
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Antigenic Blocking Peptide Polypyrimidine tract-binding protein 1 Antibody
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Verified Applications
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Immunodepletion, Immunocompetition
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Peptide Description
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Synthetic peptide corresponding to amino acids within region 150-200 on human Polypyrimidine tract-binding protein 1.
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20?C for long term storage
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Application Protocol
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Immunodepletion, Immunocompetition
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Refer to competition assay protocol
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Protein
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Uniprot #
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P26599
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Overview
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Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 (PubMed:15009664). In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:21518806).
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Molecular Function
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mRNA binding
poly-pyrimidine tract binding
pre-mRNA binding
RNA binding
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Subcellular Location
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Nucleus
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Structure
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Monomer.
Part of a ternary complex containing KHSRP, PTBP1, PTBP2 and HNRPH1.
Interacts with RAVER1 and SFPQ.
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Alternative Nomenclature
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57 kDa RNA-binding protein PPTB-1 antibody
Heterogeneous nuclear ribonucleoprotein I antibody
Heterogeneous Nuclear Ribonucleoprotein Polypeptide I antibody
HNRPI antibody
MGC10830 antibody
MGC8461 antibody
Polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I) antibody
Polypyrimidine Tract Binding Protein 1 antibody
pPTB antibody
PTB 1 antibody
PTB 2 antibody
PTB 3 antibody
PTB 4 antibody
PTB antibody
PTB T antibody
PTBP 1 antibody
PTBP1 antibody
PTBP1_HUMAN antibody
PTBT antibody
RNA Binding Protein antibody
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