General Information |
|
Product |
RUNX2 Antibody FITC-Conjugated |
Description |
FITC-Conjugated Runt-related transcription factor 2 isoform 4 Antibody |
Verified Applications |
ELISA, WB |
Host |
Rabbit |
Species Cross Reactivity |
Bovine, Human, Monkey, Panda |
Immunogen |
Synthetic peptide taken within amino acid region 10-50 on human RUNX2 protein. |
Accession # |
NCBI: XP_001100855.1 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.53 µg/µl in antibody stabilization buffer |
Form |
FITC-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
DB |
1:10,000 |
ELISA |
1:10,000 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. |
Molecular Function |
DNA-binding; Transcription Regulation |
Subcellular Location |
Nucleus |
Structure |
Heterodimer of an alpha and a beta subunit. The alpha subunit binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Interacts with XRCC6 (Ku70) and XRCC5 (Ku80). Interacts with HIVEP3. Interacts with IFI204. I |
Alternative Nomenclature |
Acute myeloid leukemia 3 protein antibody Alpha subunit 1 antibody AML3 antibody CBF alpha 1 antibody CBFA1 antibody CCD1 antibody Cleidocranial dysplasia 1 antibody Core binding factor runt domain alpha subunit 1 antibody Core binding factor subunit alpha 1 antibody Oncogene AML 3 antibody OSF 2 antibody Osteoblast specific transcription factor 2 antibody PEBP2 alpha A antibody PEBP2A1 antibody PEBP2A2 antibody Polyomavirus enhancer-binding protein 2 alpha A subunit antibody Runt domain antibody Runt related transcription factor 2 antibody SL3 3 enhancer factor 1 alpha A subunit antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
RUNX2-201AP | |||
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P-RUNX2 | |||
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RUNX2-BIOTIN | |||
|
PC-RUNX2 | |||
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