General Information |
|
Product |
TLR7 Antibody Western Blot Positive Control |
Description |
Western Blot Positive Control Toll-like receptor 7 precursor Antibody |
Verified Applications |
WB |
Immunogen |
Purified Protein |
Accession # |
NCBI: NP_057646.1 |
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|
Quantity |
5 Applications |
Volume |
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Form |
Western Blot Positive Control |
Storage |
-20⁰C for long term storage |
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Western Blot |
1:500 |
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Uniprot # |
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Overview |
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). |
Molecular Function |
Receptor, double-stranded RNA bindng, single-stranded RNA binding |
Subcellular Location |
Endoplasmic reticulum membrane; Single-pass type 1 membrane protein, Endosome, Lysosome, Cytoplasmic vesicle |
Expression |
Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells. |
Structure |
Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1 (By similarity). |
Alternative Nomenclature |
PRO285 antibody TLR 7 antibody Toll like receptor 7 antibody UNQ248 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
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TLR-701AP | |||
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TLR7-FITC | |||
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P-TLR7 | |||
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TLR7-BIOTIN | |||
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