General Information

Product

MTAP Antibody

Description

Affinity Purified Methylthioadenosine Phosphorylase Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 233-283 on human methylthioadenosine phosphorylase protein.

Accession #

GenBank: AAG38871.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q13126

Overview

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.

Molecular Function

Phosphorylase activity; S-methyl-5-thioadenosine phosphorlase activity;  Glycosyl transferase; Purine Salvage

Subcellular Location

Cytoplasm; Nucleus

Expression

Ubiquitously expressed.

Structure

Homotrimer

Alternative Nomenclature

5' methylthioadenosine phosphorylase antibody

BDMF antibody

c86fus antibody

DMSFH antibody

DMSMFH antibody

Epididymis luminal protein 249 antibody

HEL 249 antibody

LGMBF antibody

MeSAdo phosphorylase antibody

Methylthioadenosine phosphorylase antibody

MSAP antibody

MTA phosphorylase antibody

MTAP antibody

MTAPase antibody

S methyl 5 thioadenosine phosphorylase antibody

General Information

Product

LOXL1 Antibody

Description

Affinity Purified Loxl1 protein Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 570-607 on rat LOXL1 protein.

Accession #

GenBank: AAH03973.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.66 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:20,000-1:50,000

Western Blot

1:500-1:1,000

Protein

Uniprot #

P97873

Overview

Active on elastin and collagen substrates.

Molecular Function

Copper ion binding, oxidereductase activity acting on the CH-NH2 group of donors and oxygen as accecptor

Subcellular Location

secreted, extracellular space

Alternative Nomenclature

Lysyl oxidase like 1 antibody

LOL antibody

Lysyl oxidase homolog 1 antibody

Lysyl oxidase like protein 1 antibody

General Information

Product

EAAT2 Antibody

Description

Affinity Purified Excitatory amino acid transporter 2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to C terminal amino acids 550-574 of Human EAAT2. 

Sequence:

KVTLAANGKSADCSVEEEPWKREK

Accession #

NCBI:  NP_004162.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.54 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Dot Blot

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P43004

Overview

Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.

Molecular Function

Glutamate:sodium symporter activity, L-glutamate transmembrane transporter activity, sodium:dicarboxylate symporter activity

Subcellular Location

Membrane, multi-pass membrane protein

Alternative Nomenclature

Excitatory amino acid transporter 2 antibody

Excitotoxic amino acid transporter 2 antibody

Glial high affinity glutamate transporter antibody

GLT1 antibody

Glutamate aspartate transporter II antibody

Glutamate transporter 1 antibody

Glutamate/aspartate transporter II antibody

SLC1A2 antibody

Sodium dependent glutamate aspartate transporter 2 antibody

Solute carrier family 1 member 2 antibody

General Information

Product

GABA B Receptor 2 Antibody

Description

Affinity Purified Gamma-aminobutyric acid receptor subunit beta-2 Antibody C-epitope

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Cat

Immunogen

Synthetic peptide taken within amino acid region 350-400 on human gamma-aminobutyric acid receptor subunit beta-2 protein.

Accession #

NCBI:  NP_068711.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P47870

Overview

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.

Molecular Function

Chloride channel activity; GABA-A receptor activity; Inhibitory extracellular ligand-gated ion channel activity

Subcellular Location

Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein

Expression

Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression.

Structure

Binds UBQLN1. Interacts with KCT8, KCTD12 and KCTD16; this interaction determines the pharacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents. Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains.

Alternative Nomenclature

GABA-B-R2 antibody

Gamma aminobutyric acid (GABA) B receptor 2 antibody

Gb1 antibody

GPRC3A antibody

Seven transmembrane helix receptor antibody

General Information

Product

GABA B Receptor 2 Antibody

Description

Affinity Purified Gamma-aminobutyric acid receptor subunit beta-2 Antibody N-epitope

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1-50 on human gamma-aminobutyric acid A receptor beta 2 protein.

Accession #

GenBank: ACY69094.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P47870

Overview

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.

Molecular Function

Chloride channel activity; GABA-A receptor activity; Inhibitory extracellular ligand-gated ion channel activity

Subcellular Location

Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein

Expression

Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression.

Structure

Binds UBQLN1. Interacts with KCTD8, KCTD12 and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, althoughto different extents. Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains.

Alternative Nomenclature

GABA-B-R2 antibody

Gamma aminobutyric acid (GABA) B receptor 2 antibody

Gb1 antibody

GPRC3A antibody

Seven transmembrane helix receptor antibody

General Information

Product

Phospho-SMOX Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Drosophila melanogaster

Immunogen

Synthetic peptide taken within amino acid region 434-484 on D. melanogaster SMOX protein.

Accession #

GenBank: AAC83344.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75-0.95 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:250

Protein

Uniprot #

Q9TZQ2

Overview

axon guidance; dendrite morphogenesis;

determination of adult lifespan; imaginal disc-derived wing morphogenesis; mushroom body development; negative regulation of autophagy; neuron development; regulation of cell proliferation involved in imaginal disc-derived wing morphogenesis; regulation of mitotic cell cycle; transcription, DNA-templated; transforming growth factor beta receptor signaling pathway

Molecular Function

Chromatin DNA binding; Sequence-specific DNA binding transcription factor activity

Structure

Belongs to the dwarfin/SMAD family.

Contains 1 MH1 (MAD homology 1) domain.

Contains 1 MH2 (MAD homology 2) domain.

Alternative Nomenclature

C20orf16 antibody

Flavin containing amine oxidase antibody

Flavin containing spermine oxidase antibody

PAO 1 antibody

PAO antibody

PAOH1 antibody

Polyamine oxidase 1 antibody

Putative cyclin G1 interacting protein antibody

SMO antibody

Spermine oxidase antibody

General Information

Product

SMOX Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Drosophila melanogaster

Immunogen

Synthetic peptide taken within amino acid region 434-484 on D. melanogaster SMOX protein.

Accession #

GenBank: AAC83344.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75-0.95 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:250

Protein

Uniprot #

Q9TZQ2

Overview

axon guidance;

dendrite morphogenesis;

determination of adult lifespan;

imaginal disc-derived wing morphogenesis ;

mushroom body development;

negative regulation of autophagy;

neuron development;

regulation of cell proliferation involved in imaginal disc-derived wing morphogenesis;

regulation of mitotic cell cycle;

transcription, DNA-templated;

transforming growth factor beta receptor signaling pathway;

Molecular Function

Chromatin DNA binding; Sequence-specific DNA binding transcription factor activity

Structure

Belongs to the dwarfin/SMAD family.

Contains 1 MH1 (MAD homology 1) domain.

Contains 1 MH2 (MAD homology 2) domain.

Alternative Nomenclature

C20orf16 antibody

Flavin containing amine oxidase antibody

Flavin containing spermine oxidase antibody

PAO 1 antibody

Polyamine oxidase 1 antibody

Putative cyclin G1 interacting protein antibody

SMO antibody

Spermine oxidase antibod

General Information

Product

GTP cyclohydrolase 1 Antibody

Description

Affinity Purified GTP cyclohydrolase 1 Antibody C-epitope

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 25-75 on mouse GTPCHI protein.

Accession #

GeneBank: AAH05643

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.73-1.01 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:20,000

ELISA

1:20,000

Western Blot

1:500-1:750

Protein

Uniprot #

Q05915

Overview

Positively regulates nitric oxide synthesis in endothelial cells.  Invovled in dopamine synthesis and pain sensitivity and persistence.

Molecular Function

Cofactor biosynthesis; GTP binding; Coenzyme binding; Calcium ion binding

Subcellular Location

Cytoplasm; Nucleus

Structure

Toroid-shaped homodecamer.  Composed of two pentamers of five dimers.

Alternative Nomenclature

dystonia 14 antibody

DYT 5 antibody

DYT14 antibody

DYT5a antibody

GCH antibody

GTP CH 1 antibody

GTP cyclohydrolase 1 (dopa responsive dystonia) antibody

Guanosine 5' triphosphate cyclohydrolase I antibody

HPABH4B antibody

General Information

Product

GTP cyclohydrolase 1 Antibody Affinity Purified

Description

Affinity Purified GTP cyclohydrolase 1 Antibody N-epitope

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

N-epitope synthetic peptide taken within amino acid region 1-50 on GTPCHI protein.

Accession #

GeneBank: AAH05643

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68-0.98 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:20,000

ELISA

1:20,000

Western Blot

1:500-1:750

Protein

Uniprot #

Q05915

Overview

Positively regulates nitric oxide synthesis in endothelial cells.  Invovled in dopamine synthesis and pain sensitivity and persistence.

Molecular Function

Cofactor biosynthesis; GTP binding; Coenzyme binding; Calcium ion binding

Subcellular Location

Cytoplasm; Nucleus

Structure

Toroid-shaped homodecamer.  Composed of two pentamers of five dimers.

Alternative Nomenclature

dystonia 14 antibody

DYT 5 antibody

DYT14 antibody

DYT5a antibody

GCH antibody

GTP CH 1 antibody

GTP cyclohydrolase 1 (dopa responsive dystonia) antibody

Guanosine 5' triphosphate cyclohydrolase I antibody

HPABH4B antibody

General Information

Product

SERHL Antibody Antigenic Blocking Peptide

Description

Antigenic Blocking Peptide Serine hydrolase-like protein 2 isoform a Antibody Mid-Region

Verified Applications

Immunodepletion, Immunocompetition

Immunogen

Synthetic peptide

Accession #

NCBI:  NP_055324.2

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Determinant

Mid-Region

Storage

-20⁰C for long term storage

Application Protocol

Western Blot

1:500

Protein

Uniprot #

Q9H4I8

Overview

Probable serine hydrolase. May be related to cell muscle hypertrophy.

Molecular Function

Hydrolase activity

Subcellular Location

Cytoplasm, perinuclear region; peroxisome. (Note: Concentrated in perinuclear vesicles. May be located in peroxisomes)

Alternative Nomenclature

BK126B4.1 antibody

BK126B4.2 antibody

HS126B42 antibody 

serine hyrdolase 1 antibody