General Information

Product

P2Y2 Antibody

Description

Affinity Purified P2Y purinoceptor 2 Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Cat, Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 360-410 on rat P2Y2 protein.

Accession #

GenBank: EAW74883.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.52-0.68 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

A0A024R5N1

Overview

Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.

Molecular Function

G-protein coupled receptor, Receptor, Transducer

Subcellular Location

Membrane

Expression

Spleen, testis, kidney, liver, lung, heart and brain.

Structure

Belongs to the G-protein coupled receptor 1 family.

Alternative Nomenclature

ATP receptor antibody

HP2U antibody

Human P2U nucleotide receptor mRNA complete cds antibody

MGC20088 antibody

MGC40010 antibody

P2RU1 antibody

P2RY2 antibody

P2U antibody

P2U nucleotide receptor antibody

P2U purinoceptor 1 antibody

P2U receptor 1 antibody

P2U1 antibody

P2UR antibody

P2Y purinoceptor 2 antibody

P2Y2 antibody

P2Y2R antibody

Purinergic receptor antibody

Purinergic receptor P2Y G protein coupled 2 antibody

Purinergic receptor P2Y2 antibody

Purinoceptor P2Y2 antibody

General Information

Product

Phospho Ephrin receptor A4 Antibody Affinity Purified

Description

Affinity Purified Phosphorylated Ephrin type-A receptor 4 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Immunogen

Synthetic peptide taken within amino acid region 570-630 on human EPHA R4 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q03137

Overview

Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium.

Molecular Function

ATP-binding, Nucleotide-binding

Subcellular Location

Cell membrane; Single-pass type I membrane protein

Expression

Highest expression in the adult brain and retina and also detectable in kidney, lung, skeletal muscle and thymus. Not detected in heart and liver.

Structure

Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. Interacts (phosphorylated at position Tyr-602) with FYN. Interacts (via

Alternative Nomenclature

Cek 8 antibody

EK8 antibody

eph receptor a4 antibody

EPH-like kinase 8 antibody

EphA4 antibody

Ephrin receptor Eph A4 antibody

hEK8 antibody

Receptor protein tyrosine kinase HEK 8 antibody

Sek 1 antibody

SEK antibody

TYRO 1 protein tyrosine kinase antibody

Tyrosine protein kinase receptor SEK antibody

General Information

Product

Solute carrier family 35 member E4 Antibody Affinity Purified

Description

Affinity Purified Solute carrier family 35, member E4 (Slc35e4), mRNA Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 170-200 on Slc35E4 protein.

Accession #

NCBI: NM_153316.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.67-0.98 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Dot Blot

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q5RKL7

Overview

Putative transporter

Subcellular Location

Membrane

Structure

Belongs to the TPT transporter family. SLC35E subfamily

Alternative Nomenclature

MGC129826 antibody

SLC35E4 antibody

General Information

Product

Sodium / Hydrogen Exchanger 3 Antibody Affinity Purified

Description

Affinity Purified Sodium/Hydrogen Exchanger 3 isoform 1 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 790-835 on Slc9A3 protein.

Accession #

NCBI:  NP_004165.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P48764

Overview

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.

Molecular Function

PDZ domain binding; Sodium:proton antiporter activity

Subcellular Location

Apical cell membrane; Multi-pass membrane protein

Structure

Binds SLC9A3R1 and SLC9A3R2. Interacts with CHP1, CHP2 and SHANK2. Interacts with PDZK1 (via C-terminal PDZ domain) (By similarity). Interacts with PDZD3 and interactions decrease in response to elevated calcium ion levels.

Alternative Nomenclature

MGC126718 antibody

MGC126720 antibody

NHE3 antibody

SLC9A 3 antibody

Sodium/hydrogen exchanger 3 antibody

Solute carrier family 9 member 3 antibody

General Information

Product

SUR1 Antibody

Description

Affinity Purified ATP-binding cassette sub-family C member 8 Antibody

Verified Applications

ELISA, IHC-Fr, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to positions 1560-1582.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.6 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000-1:100,000

ELISA

1:10,000-1:100,000

Western Blot

1:500

Protein

Uniprot #

Q09429

Overview

Putative subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K+ channels and insulin release.

Molecular Function

Receptor, ATPase activity, coupled to transmembrane movement of substances, ATP binding

Subcellular Location

Membrane; Multi-pass membrane protein

Structure

Interacts with KCNJ11.

Alternative Nomenclature

ABC36 antibody

Abcc8 antibody

ATP binding cassette sub family C (CFTR/MRP) member 8 antibody

HHF1 antibody

HI antibody

HRINS antibody

MRP8 antibody

PHHI antibody

Sulfonylurea receptor (hyperinsulinemia) antibody

SUR antibody

SUR1 antibody

SUR1delta2 antibody

TNDM2 antibody

General Information

Product

TRPM8 Antibody Affinity Purified

Description

Affinity Purified Transient receptor potential cation channel subfamily M member 8 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Rat, Mouse

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on TRPM8 protein.

Accession #

NCBI:  NP_599198.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.6 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q8R455

Overview

Involved in detection of sensations such as coolness, activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH

Molecular Function

Calcium channel activity

Subcellular Location

cell membrane, multi-pass membrane protein, membrane raft. (Note: Localizes to membrane rafts but is also loated in the cell membrane outside of these regions where channel response to cold is enhanced compared to membrane rafts)

Expression

Expressed in dorsal root and trigeminal ganglia. Specifically expressed in a subset of sensory neurons, including cold-sensitive neurons in trigeminal neurons.

Alternative Nomenclature

Long transient receptor potential channel 6 antibody

LTrpC6 antibody

Short form of the TRPM8 cationic channel antibody

Transient receptor potential cation channel subfamily M member 8 antibody

Transient receptor potential p8 antibody

TRPP8 antibody

General Information

Product

Aquaporin 12 Antibody

Verified Applications

ELISA, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 240-290 on mouse Aquaporin 12 protein.

Accession #

GenBank:  EDL39975

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.61-0.67 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q3V2I1

Overview

Water transport activity

Molecular Function

Transport

Subcellular Location

Membrane

Expression

Cytoplasm; plasma membrane; integral component of membrane

Structure

Contain two tandem repeats each with three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala

Alternative Nomenclature

AQP 12 antibody

AQP 12A antibody

AQPX2 antibody

Aquaporin 12 antibody

Aquaporin 12A antibody

Aquaporin X2 antibody

General Information

Product

Glucose Transporter GLUT1 Antibody

Description

Glucose transporter glycoprotein GLUT1 Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Sheep

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequences on GLUT1 protein.

Accession #

GenBank: AAC28635.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:12,000

ELISA

1:12,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:5,000

Protein

Uniprot #

P11166

Overview

Facilitative glucose transporter. May be responsible for constitutive or basal glucose uptake.

Molecular Function

Sugar Transport

Subcellular Location

Cell membrane; Multi-pass membrane protein; melanosome

Expression

Detected in erythrocytes. Variable expression in many human tissues.

Structure

Transmembrane helix

Alternative Nomenclature

DYT17 antibody

DYT18 antibody

erythrocyte/brain antibody

Erythrocyte/hepatoma glucose transporter antibody

facilitated glucose transporter member 1 antibody

Glucose transporter type 1 erythrocyte/brain antibody

GLUT1DS antibody

GLUTB antibody

GT1 antibody

GTG1 antibody

Gtg3 antibody

HepG2 glucose transporter antibody

MGC141895 antibody

MGC141896 antibody

PED antibody

RATGTG1 antibody

SLC2A1 antibody

Solute carrier family 2, facilitated glucose transporter member 1 antibody

General Information

Product

Phospho-Aquaporin 2 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Sheep, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 200-240 on rat Aquaporin 2 protein.  Phosphorylated Serine 218 residue.

Accession #

NCBI:  NP_037041

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-0.62 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P34080

Overview

Forms a water-specific channel that provies the plasma mebranes of red cells and kidney proximal tubules with water permeability.

Molecular Function

Transport

Subcellular Location

Apical cell membrane; Multiplass membrane protein; Basolateral cell membrane

Expression

Renal collecting tubules

Structure

Contain two tandem repeats each with three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala

Alternative Nomenclature

ADH water channel antibody

Aquaporin 2 collecting duct antibody

Aquaporin-CD antibody

Aquaporine 2 antibody

Collecting duct water channel protein antibody

MGC34501 antibody

Water channel aquaporin 2 antibody

Water channel protein for renal collecting duct antibody

WCHCD antibody

General Information

Product

PGCG Antibody

Description

Affinity Purified Guanylyl Cyclase G Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic C-terminal peptide corresponding to unique amino acid sequences on Particulate Guanylyl Cyclase G protein.

Accession #

GenBank: AF024622.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75-1.20 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Western Blot

1:500

Protein

Uniprot #

P55205

Overview

Binds to a yet not identified ligand.

Possible role in processes such as water and electrolyte balance, and muscle contraction.

Molecular Function

Lyase, Receptor

Subcellular Location

Isoform 1:  Cell membrane; Single-pass type I membrane protein.  Isoform 2:  Cytoplasm

Expression

Expressed in lung, kidney and skeletal muscle. Low levels in intestine.

Structure

Homodimer or heterodimer with NPR1.

Alternative Nomenclature

CYGF antibody

GC F antibody

guanylate cyclase 2D-like, membrane (retina-specific) antibody

Guanylate cyclase 2F antibody

GUC2DL antibody

GUC2F antibody

Gucy2f antibody

RETGC-2 antibody

retinal antibody

Rod outer segment membrane guanylate cyclase 2 antibody

ROS-GC2 antibody