General Information

Product

Ephrin Receptor A1 Antibody

Description

Affinity Purified Ephrin type-A receptor 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 55-605 on human Ephrin type-A receptor 1.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P21709

Overview

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.

Molecular Function

ATP binding; protein kinase activity; protein kinase binding; transmembrane-ephrin receptor activity

Subcellular Location

Cell membrane; Single-pass type I membrane protein

Expression

Overexpressed in several carcinomas.

Structure

Homodimer. Forms a signaling complex with LCK; PTK2B/PYK2 and PI3-kinase upon activation by EFNA1; regulates T-lymphocytes migration. Interacts (via SAM domain) with ILK (via ANK repeats); stimulated by EFNA1 but independent of the kinase activity of EPHA

Alternative Nomenclature

EPH antibody

EPH receptor A1 antibody

Eph tyrosine kinase 1 antibody

EphA1 antibody

Ephrin receptor Eph A1 antibody

Ephrin type-A receptor 1 antibody

EPHT 1 antibody

Erythropoietin producing hepatoma amplified sequence antibody

Esk antibody

Esk antibody

hEpha1 antibody

MGC163163 antibody

Oncogene EPH antibody

Soluble EPHA1 variant 1 antibody

Soluble EPHA1 variant 2 antibody

Tyrosine protein kinase receptor EPH antibody

General Information

Product

ENT1 Antibody

Description

Affinity Purified Equilibrative nitrobenzylthioinosine-sensitive nucleoside transporter ENT1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid reigon 410-460 on mouse Equilibrative nitrobenzylthioinosine-sensitive nucleoside transporter ENT1 protein.

Accession #

GenBank: AAF64035.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q9JIM1

Overview

Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Resistant to dipyridamole and dilazep inhibition (anticancer chemotherapeutics drugs).

Molecular Function

Nucleoside transmembrane transporter activity

Subcellular Location

Cell membrane; Basolateral cell membrane; Apical cell membrane

Expression

Highly expressed in heart, spleen, lung, liver and testis. Lower level of expression in brain and kidney.

Structure

Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.

Alternative Nomenclature

Equilibrative NBMPR-sensitive nucleoside transporter antibody

Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter antibody

Equilibrative nucleoside transporter 1 antibody

es-type antibody

Nucleoside transporter, es-type antibody

Slc29a1 antibody

solute carrier family 29 (equilibrative nucleoside transporter), member 1 antibody

Solute carrier family 29 member 1 antibody

General Information

Product

GPCR GPR7 Antibody

Description

Affinity Purified Neuropeptides B/W receptor type 1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Immunogen

Synthetic peptide taken within amino acid region 1-50 on human neuropeptides B/W receptor type 1 protein.

Accession #

NCBI:  NP_005276

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P48145

Overview

Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. Has a higher affinity for neuropeptide B.

Molecular Function

G-protein coupled receptor, Receptor, Transducer.

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Expression

Found in cerebellum and frontal cortex. Detected at high levels in hippocampus, amygdala and trachea; at moderate levels in fetal brain, pituitary gland and prostate. Not in caudate, accumbens, kidney or liver. Also detected at high levels in lung carcinoma.

Structure

Belongs to the G-protein coupled receptor 1 family.

Alternative Nomenclature

G protein coupled receptor 7 
GPR7 
MGC129755 
Neuropeptides B and W receptor 1 
NPB and NPW receptor 1 
NPBWR1 
opioid somatostatin like receptor 7 

General Information

Product

Sodium / Hydrogen Exchanger 1 Antibody

Description

Affinity Purified Sodium/hydrogen exchanger 1 / SLC9A1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 700-750 on human Sodium/hydrogen exchanger 1 / SLC9A1 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:50-1:150

Immunohistochemistry

1:50-1:150

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P19634

Overview

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.

Molecular Function

calcium-dependent protein binding

calmodulin binding

phosphatidylinositol-4,5-bisphosphate binding

potassium:proton antiporter activity

protein binding, bridging

protein complex scaffold

protein phosphatase 2B binding

sodium:proton antiporter activity

Subcellular Location

Membrane; Multi-pass membrane protein

Endoplasmic reticulum membrane; Multi-pass membrane protein

Cell membrane; Multi-pass membrane protein

Expression

Kidney and intestine.

Alternative Nomenclature

amiloride-sensitive antibody

APNH antibody

APNH1 antibody

Na Li countertransporter antibody

Na(+)/H(+) antiporter antibody

Na(+)/H(+) exchanger 1 antibody

NHE1 antibody

SLC9A1 antibody

Sodium hydrogen exchanger 1 antibody

solute carrier family 9 antibody

Solute carrier family 9 member 1 antibody

Solute carrier family 9 sodium hydrogen exchanger isoform 1 antiporter Na+ H+ amiloride sensitive antibody

Solute carrier family 9 subfamily A (NHE1 cation proton antiporter 1) member 1 antibody

  General Information

Product

ASIC2 Antibody

Description

Affinity Purified Acid-sensing ion channel 2 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 450-512 on human Acid-sensing ion channel 2 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:2,500-1:5,000

Protein

Uniprot #

Q16515

Overview

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li+ and K+. Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.

Molecular Function

acid-sensing ion channel activity; ion gated channel activity; ligand-gated sodium channel activity

Subcellular Location

Cell membrane; Multi-pass membrane protein

Expression

Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary.

Structure

Homotrimer or heterotrimer with other ASIC proteins.

Alternative Nomenclature

ACCN1 antibody

Acid sensing ion channel 2 antibody

Amiloride sensitive brain sodium channel antibody

Amiloride sensitive cation channel 1 neuronal antibody

ASIC2 antibody

BNaC1 antibody

Brain sodium channel 1 antibody

Degenerin antibody

Mammalian degenerin homolog antibody

MDEG antibody

Neuronal amiloride sensitive cation channel 1 antibody

General Information

Product

SLC26A6 Antibody

Description

Affinity Purified Solute carrier family 26 member 6 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to amino acids within region700-759 on human SCL26A6 protein.

Physical Properties

Quantity

100 ug

Concentration

0.5-1.5 ﾵg/ﾵl in antibody stabilization buffer

Immunoglobulin

IgG

Conjugate

Unconjugated

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20ﾡC for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:50-1:100

Immunofluorescence

1:50-1:100

Immunohistochemistry

1:50-1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q9BXS9

Subcellular Location

Endoplasmic reticulum, Plasma membrane

Structure

Transmembrane, Transmembrane helix

Alternative Nomenclature

Anion exchange transporter antibody

Anion transporter 1 antibody

DKFZp586E1422 antibody

Pendrin L1 antibody

Pendrin like protein 1 antibody

Pendrin-L1 antibody

Pendrin-like protein 1 antibody

S26A6_HUMAN antibody

SLC26A6 antibody

Solute carrier family 26 member 6 antibody

Sulfate anion transporter antibody

Anion exchange transporter antibody

Anion transporter 1 antibody

DKFZp586E1422 antibody

Pendrin L1 antibody

Pendrin like protein 1 antibody

Pendrin-L1 antibody

Pendrin-like protein 1 antibody

S26A6_HUMAN antibody

SLC26A6 antibody

Solute carrier family 26 member 6 antibody

Sulfate anion transporter antibody

Anion exchange transporter antibody

Anion transporter 1 antibody

DKFZp586E1422 antibody

Pendrin L1 antibody

Pendrin like protein 1 antibody

Pendrin-L1 antibody

Pendrin-like protein 1 antibody

S26A6_HUMAN antibody

SLC26A6 antibody

Solute carrier family 26 member 6 antibody

Sulfate anion transporter antibody

General Information

Product

SLC26A3 Antibody

Description

Affinity Purified Chloride anion exchanger Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to amino acids within region 520-570 on human SCL26A3 protein.

Physical Properties

Quantity

100 ug

Concentration

0.5-1.5 ug/ul in antibody stabilization buffer

Immunoglobulin

IgG

Conjugate

Unconjugated

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20ﾡC for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:50-1:100

Immunofluorescence

1:50-1:100

Immunohistochemistry

1:50-1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P40879

Overview

Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.

Subcellular Location

Plasma membrane

Expression

Expression is significantly decreased in adenomas (polyps) and adenocarcinomas of the colon.

Structure

Transmembrane, Transmembrane helix

Alternative Nomenclature

Solute Carrier Family 26 Member 3

DRA

Solute Carrier Family 26 (Anion Exchanger), Member 3

Chloride Anion Exchanger

CLD

Solute Carrier Family 26, Member 3

Down-Regulated In Adenoma Protein

Congenital Chloride Diarrhea

Down-Regulated In Adenoma

Protein DRA

General Information

Product

SLC26A3 Antibody

Description

Affinity Purified Chloride anion exchanger Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to amino acids within region 650-700 on human SCL26A3 protein.

Physical Properties

Quantity

100 ug

Concentration

0.5-1.5 ﾵg/ﾵl in antibody stabilization buffer

Immunoglobulin

IgG

Conjugate

Unconjugated

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20ﾡC for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:50-1:100

Immunofluorescence

1:50-1:100

Immunohistochemistry

1:50-1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P40879

Overview

Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.

Subcellular Location

Plasma membrane

Expression

Expression is significantly decreased in adenomas (polyps) and adenocarcinomas of the colon.

Structure

Transmembrane, Transmembrane helix

Alternative Nomenclature

Solute Carrier Family 26 Member 3

DRA

Solute Carrier Family 26 (Anion Exchanger), Member 3

Chloride Anion Exchanger

CLD

Solute Carrier Family 26, Member 3

Down-Regulated In Adenoma Protein

Congenital Chloride Diarrhea

Down-Regulated In Adenoma

Protein DRA