General Information |
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Product |
CTLA4 Positive Control |
Description |
Western Blot Positive Control Cytotoxic T-lymphocyte protein 4 |
Verified Applications |
WB |
Accession # |
GenBank: AAL07473.1 |
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|
Quantity |
5 Applications |
Volume |
Inquire |
Concentration | The concentration of the sample is empirically set so that 20 µl per lane in Western and blotted with corresponding affinity purified antibody will give a clean band with a high signal to noise ratio on the gel. |
Form |
Western Blot Positive Control |
Storage |
-20⁰C for long term storage |
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Western Blot |
1:500 |
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Uniprot # |
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Overview |
Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family lingands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory correceptor CD28. |
Molecular Function |
Adaptive Immunity |
Subcellular Location |
Cell membrane; Single pass type I membrane protein |
Expression |
Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory correceptor, on the cell surface following activation. |
Structure |
Homodimer; disfulfide-linked |
Alternative Nomenclature |
CD 152 antibody CD antibody CD152 antigen antibody CD152 isoform antibody Celiac disease 3 antibody CELIAC3 antibody CTLA-4 antibody Cytotoxic T cell associated 4 antibody Cytotoxic T lymphocyte associated serine esterase 4 antibody GRD4 antibody GSE antibody ICOS antibody IDDM12 antibody Ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4 antibody OTTHUMP00000216623 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
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CTLA4-101AP | |||
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CTLA4-FITC | |||
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P-CTLA4 | |||
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CTLA4-BIOTIN | |||
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