General Information |
|
Product |
Insulin Receptor Positive Control |
Description |
Western Blot Positive Control Insulin receptor alpha and beta |
Verified Applications |
WB |
Immunogen |
Purified Protein |
Accession # |
NCBI: NM_001079817.1 |
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|
Quantity |
5 Applications |
Volume |
Inquire |
Form |
Western Blot Positive Control |
Storage |
-20⁰C for long term storage |
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|
Western Blot |
1:500 |
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|
Uniprot # |
|
Overview |
Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. |
Molecular Function |
Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Subcellular Location |
Cell membrane; Single-pass type I membrane protein |
Expression |
Isoform Long and isoform Short are predominantly expressed in tissue targets of insulin metabolic effects: liver, adipose tissue and skeletal muscle but are also expressed in the peripheral nerve, kidney, pulmonary alveoli, pancreatic acini, placenta vascular endothelium, fibroblasts, monocytes, granulocytes, erythrocytes and skin. Isoform Short is preferentially expressed in fetal cells such as fetal fibroblasts, muscle, liver and kidney. Found as a hybrid receptor with IGF1R in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Overexpressed in several tumors, including breast, colon, lung, ovary, and thyroid carcinomas. |
Structure |
Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. |
Alternative Nomenclature |
CD220 antibody HHF5 antibody HIR A antibody INSR alpha antibody Insulin receptor antibody Insulin receptor subunit alpha antibody IR antibody HHF5 antibody human insulin receptor antibody Insulin receptor subunit beta antibody IR 1 antibody |
Protein information supplied by UniProt.
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