General Information

Product

Human Lactoferrin Antibody

Verified Applications

ELISA, ICC/IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Full length native protein purified human Lactoferrin.

Accession #

GeneBank: AAA59511

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.8 µg/µl in antibody stabilization buffer

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P02788

Overview

Iron binding transport proteins which bind two Fe3+ ions in association with the binding of an anion usually bicarbonate. Binds to bacterial surface and is crucial for the bactericidal functions.  Has some antiviral activity against papillomavirus infection.

Molecular Function

DNA binding, Heparin Binding, Iron, metal Binding, Immunity

Subcellular Location

Secreted; Cytoplasmic granule; Nucleus

Expression

Saliva, tears, serum, plasma, urine, distal collecting tubules in the medulla, peripheral blood leukocytes.

Structure

Belongs to transferrin family; Contains 2 transferrin-like domains

Alternative Nomenclature

CKRX antibody

GIG12 antibody

Growth inhibiting protein 12 antibody

HLF2 antibody

Homo sapiens chemokine receptor X antibody

Kaliocin 1 antibody

Lactoferrin antibody

Lactoferroxin A antibody

Lactoferroxin B antibody

Lactoferroxin-C antibody

Lactotransferrin antibody

LF antibody

LTF antibody

Neutrophil lactoferrin antibody

Talalactoferrin alfa antibody

General Information

Product

Prominin 2 Antibody

Verified Applications

CM, ELISA, ICC/IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to Human Prominin 2 amino acids 315-338. 

Sequence:

RTLELGADFSQVPSVDHVLHQLKG

Accession #

NCBI:  NP_653308.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:100

DB

1:2,000

ELISA

1:2,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q8N271

Molecular Function

Cholesterol binding

Subcellular Location

Apical cell membrane, multi-pass membrane protein (Note: Colocalizes with PROM1. Associates with membrane in a cholesterol-dependent manner. Localizes to the apical and basolateral membranes of epithelial cells).

Expression

Present in saliva within small membrane particles (at protein level). Expressed in kidney, prostate, trachea, esophagus, salivary gland, thyroid gland, mammary gland adrenal gland, placenta, stomach, spinal cord and liver. In submucosal tumor, expressed in spindle-shaped or stellate stromal cells. Expressed in prostate cancer cell lines.

Alternative Nomenclature

MGC138714 antibody

PROM 2 antibody

Prominin like protein 2 antibody

Prominin related protein antibody

Prominin-2 antibody

General Information

Product

Phospho Survivin Antibody Affinity Purified

Description

Affinity Purified Phosphorylated Baculoviral IAP repeat-containing protein 5 isoform 2 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Phosphorylated synthetic peptide corresponding to unique amino acid sequences on human Survivin protein.

Accession #

NCBI:  NP_001012270.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-1.50 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O15392

Overview

Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.

Molecular Function

Protease inhibitor, Repressor, Thiol protease inhibitor

Subcellular Location

Cytoplasm, Nucleus, Chromsome, Centromere, Cytoskeleton, Spindle, Kinetochore, Midbody

Expression

Expressed only in fetal kidney and liver, and to lesser extent, lung and brain. Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas. Also expressed in various renal cell carcinoma cell lines.

Structure

Monomer or Homodimer.

Alternative Nomenclature

API4 antibody

Apoptosis Inhibitor 4 antibody

Apoptosis inhibitor survivin antibody

Baculoviral IAP repeat-containing protein 5 antibody

BIRC5 antibody

EPR 1 antibody

IAP4 antibody

Survivin variant 3 alpha antibody

SVV antibody

TIAP antibody

General Information

Product

ROCK2 Antibody

Description

Affinity Purified Rho-associated protein kinase 2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1300-1388 on human ROCK2 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.57 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DOT Blot

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O75116

Overview

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4.

Molecular Function

Kinase, Serine/threonine-protein kinase, Transferase

Subcellular Location

Cytoplasm, Cell membrane; Peripheral membrane protein, Nucleus

Structure

Homodimer. Interacts with IRS1, RHOB and RHOC. Interacts with RHOA (activated by GTP), PPP1R12A, CHORDC1, SORL1, EP300 and BRCA2. Interacts with NPM1 and this interaction enhances its activity. Interacts with RAF1.

Alternative Nomenclature

coiled-coil-containing protein kinase 2 antibody

KIAA0619 antibody

p164 ROCK 2 antibody

Rho associated, coiled coil containing protein kinase II antibody

ROK alpha antibody

General Information

Product

ARTS Antibody Affinity Purified

Description

Affinity Purified Septin-4 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 400-450 on SEPT4 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68-075 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O43236

Overview

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli.

Molecular Function

GTPase activity, structural molecule activity, GTP binding

Subcellular Location

Cytoplasm, cytoskeleton. (Note: In platelets, found in areas surrounding alpha-granules)

Expression

Widely expressed in adult and fetal tissues with highest expression in adult brain (at protein level), heart, liver and adrenal gland and fetal heart, kidney, liver and lung. Also expressed in colorectal cancers and malignant melanomas. Expressed in plate

Alternative Nomenclature

Apoptosis Related Protein TGFb Signalling antibody

ARTS antibody

Bradeion beta antibody

Brain protein H5 antibody

CE5B3 antibody

CE5B3 beta antibody

cell division control-related protein 2 antibody

cerebral protein 7 antibody

H5 antibody

hCDCREL-2 antibody

Hucep 7 antibody

MART antibody

Peanut-like protein 2 antibody

PNUTL2 antibody

SEP4 antibody

SEPT4 antibody

Septin-4 antibody

General Information

Product

SIRT7 Antibody

Description

Affinity Purified Sirtuin (silent mating type information regulation 2 homolog) 7 Antibody C-epitope

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 340-390 on human SIRT7 protein.

Accession #

GenBank: AAH17305.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q9NRC8

Overview

NAD-dependent protein deacetylase that specifially mediates deacetylation of histone H3 at 'Lys-18'. Displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression.

Molecular Function

Chromatin binding, NAD+ binding, NAD-dependent histone deacetylase activity (H3-K18 specific), metal ion binding

Subcellular Location

Cytoplasm, nucleus, nucleolus. (Note: Located close to the nuclear membrane when in cytoplasm. Associated with chromatin. Associated with rDNA promoter and transcribed region. Associated with nucleolar organizer regions during mitosis.

Expression

Detected in liver, spleen and testis. Detected in embryos.

Structure

Belongs to the Sirtuin Family. Class IV subfamily. Contains 1 deacetylase sirtuin-type domain.

Alternative Nomenclature

NAD dependent deacetylase sirtuin 7 antibody

Regulatory protein SIR2 homolog 7 antibody

Silent mating type information regulation 2 homolog antibody

SIR2 L7 antibody

SIR2 like protein 7 antibody

Sir2 related protein type 7 antibody

SIRT7 antibody

Sirtuin 7 antibody

Sirtuin type 7 antibody

General Information

Product

TRAF6 Antibody Affinity Purified

Description

Affinity Purified TNF receptor-associated factor 6 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on TRAF6 protein.

Accession #

NCBI:  NP_665802.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9Y4K3

Overview

Mediates synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, may be essential for formation of functional osteoclasts, seems to also play a role in dendritic cells maturation and/or activation.

Molecular Function

histone deacetylase binding, ligase activity, zinc ion binding, protein kindase B binding, protein N-terminus binding signal transducer activity

Subcellular Location

Cytoplasm, cell cortex, nucleus, lipid droplet. (Note: Found in nuclei of some aggressive B-cell lymphoma cell lines as well as in the nuclei of both resting and activated T- and B-lymphocytes. Found in punctate nuclear body protein complexes. Ubiquitinat

Expression

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Alternative Nomenclature

E3 ubiquitin-protein ligase TRAF6 antibody

Interleukin 1 signal transducer antibody

RING finger protein 85 antibody

RNF85 antibody

TNF receptor-associated factor 6, E3 ubiquitin protein ligase antibody

General Information

Product

PBR Antibody

Description

Affinity Purified Mitochondrial benzodiazepine receptor Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Rat

Immunogen

Synthetic peptide taken within amino acid region 100-150 on 18 kDa mitochondrial benzodiazepine receptor protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

.60-0.65 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P30536

Overview

Can bind protoporphyrin IX and may play a role in transport of porphyrins and heme. Promotes transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism.

Molecular Function

Benzodiazepine receptor activity, cholesterol binding

Subcellular Location

Mitochondrian membrane, Multi-pass membrane protein

Expression

Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids

Alternative Nomenclature

Benzodiazapine receptor (peripheral) antibody

Benzodiazepine peripheral binding site antibody

BPBS antibody

BZRP antibody

DBI antibody

IBP antibody

Isoquinoline carboxamide-binding protein antibody

MBR antibody

mDRC antibody

Mitochondrial benzodiazepine receptor antibody

PBR antibody

PBS antibody

Peripheral benzodiazepine receptor antibody

Peripheral benzodiazepine receptor-related protein antibody

pk18 antibody

PKBS antibody

PTBR antibody

Ptbzr antibody

PTBZR02 antibody

RATPTBZR02 antibody

translocator protein (18kDa) antibody

Translocator protein antibody

TSPO antibody

Tspo1 antibody

General Information

Product

WWOX 1/4 Antibody Affinity Purified

Description

Affinity Purified WW domain-containing Oxidoreductase isoform 1 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on WWOX 1 and WWOX4 protein.

Accession #

NCBI:  NP_057457.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.62 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000-1:100,000

ELISA

1:10,000-1:100,000

Western Blot

1:500

Protein

Uniprot #

Q9NZC7

Overview

Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.

Molecular Function

Coenzyme binding; protein dimerization activity; cofactor binding;

Subcellular Location

Cytoplasm. Nucleus. Mitochondrion. Golgi apparatus

Expression

Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines.

Structure

Interacts with TP53, p73/TP73 and MAPK8. Interacts with MAPT/TAU, RUNX2 and HYAL2 (By similarity). Forms a ternary complex with TP53 and MDM2. Interacts with ERBB4, LITAF and WBP1. Interacts with DVL1, DVL2 and DVL3. May interact with FAM189B and SCOTIN.

Alternative Nomenclature

D16S432E antibody

FOR antibody

FOR II protein antibody

FRA16D antibody

fragile 16D oxido reductase antibody

fragile site FRA16D oxidoreductase antibody

HHCMA56 antibody

PRO0128 antibody

putative oxidoreductase antibody

WW domain-containing oxidoreductase antibody

WW domain-containing protein WWOX antibody

WWOX antibody

General Information

Product

WWOX2 Antibody Affinity Purified

Description

Affinity Purified Abberant WW domain-containing Oxidoreductase Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on WWOX2 protein.

Accession #

GenBank: AAL05451.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000-1:100,000

ELISA

1:10,000-1:100,000

Western Blot

1:500

Protein

Uniprot #

Q9NZC7

Overview

Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.

Molecular Function

Coenzyme binding; protein dimerization activity; cofactor binding;

Subcellular Location

Cytoplasm. Nucleus. Mitochondrion. Golgi apparatus

Expression

Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines.

Structure

Interacts with TP53, p73/TP73 and MAPK8. Interacts with MAPT/TAU, RUNX2 and HYAL2 (By similarity). Forms a ternary complex with TP53 and MDM2. Interacts with ERBB4, LITAF and WBP1. Interacts with DVL1, DVL2 and DVL3. May interact with FAM189B and SCOTIN.

Alternative Nomenclature

FOR antibody

FOR II protein antibody

FOR1 antibody

FRA16D antibody

Fragile 16D oxido reductase antibody

Fragile site FRA16D oxidoreductase antibody

Putative oxidoreductase antibody

WOX1 antibody

WW domain containing oxidoreductase antibody

WW domain containing protein WWOX antibody

WW domain oxidoreductase antibody

WWOX antibody