General Information
|
|
Product
|
Aph 1b Antibody BIOTIN-Conjugated
|
Description
|
BIOTIN-Conjugated Presenelin-stabiliziation factor-like Antibody
|
Verified Applications
|
ELISA, WB
|
Host
|
Rabbit
|
Species Cross Reactivity
|
C. elegans, Human, Mouse, Rat
|
Immunogen
|
Synthetic peptide taken within amino acid region 235-257 of Human Presenilin stabilizing protein.
|
Specificity |
APH1B-BIOTIN does not cross react to other components of gamma secretase complex nor with other proteins. |
Physical Properties
|
|
Quantity
|
100 µg
|
Volume
|
200 µl
|
Concentration
|
0.6 µg/µl in antibody stabilization buffer
|
Form
|
BIOTIN-Conjugated
|
Clonality
|
Polyclonal
|
Storage
|
-20⁰C for long term storage
|
Application Protocol
|
|
DB
|
1:10,000
|
ELISA
|
1:10,000
|
Western Blot
|
1:500
|
Protein
|
|
Uniprot #
|
Q8WW43
|
Overview
|
Subunit of gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and beta-amyloid precursor protein.
|
Molecular Function
|
Notch signaling pathway
|
Subcellular Location
|
Membrane; Multi-pass protein
|
Expression
|
Weakly expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, skeletal muscle, heart, and brain.
|
Structure
|
Component of gamma-secretase complex. Interacts with PSEN1 and PSEN2.
|
Alternative Nomenclature
|
Anterior pharynx defective 1B like antibody
Gamma secretase subunit APH 1B antibody
Presenilin stabilisation factor like antibody
PRO1328 antibody
PSFL antibody
TAAV 688 antibody
|