General Information |
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Product |
CARD15 Positive Control |
Description |
Western Blot Positive Control Nucleotide-binding oligomerization domain-containing protein 2 Antibody |
Verified Applications |
WB |
Immunogen |
Purified Protein |
Accession # |
Gen Bank: AAH44774 |
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Quantity |
5 Applications |
Volume |
Inquire |
Form |
Western Blot Positive Control |
Storage |
-20⁰C for long term storage |
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Western Blot |
1:2,500-1:5,000 |
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Uniprot # |
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Overview |
Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response (PubMed:22607974). Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561). |
Molecular Function |
actin binding ATP binding CARD domain binding endodeoxyribonuclease activity, producing 5'-phosphomonoesters enzyme binding Hsp70 protein binding Hsp90 protein binding muramyl dipeptide binding peptidoglycan binding protein kinase binding |
Subcellular Location |
Cytoplasm Membrane Basolateral cell membrane |
Structure |
The ATG16L1-binding motif mediates interaction with ATG16L1. Intramolecular interactions between the N-terminal moiety and the leucine-rich repeats (LRR) may be important for autoinhibition in the absence of activating signal. In the absence of LRRs, the protein becomes a constitutive activator of CASP1 cleavage and proIL1B processing. |
Alternative Nomenclature |
ACUG antibody Arthrocutaneouveal granulomatosis antibody BLAU antibody CARD15 antibody Caspase recruitment domain protein 15 antibody CD antibody CLR16.3 antibody IBD1 antibody Inflammatory bowel disease protein 1 antibody LRR containing protein antibody NLR family, CARD domain containing 2 antibody NLRC2 antibody NOD like receptor C2 antibody NOD2 antibody NOD2B antibody Nucleotide binding oligomerization domain, leucine rich repeat and CARD domain containing 2 antibody PSORAS1 antibody |
Protein information supplied by UniProt.
Product | Note | Status | Price | |
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NOD2-201AP | |||
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NOD2-BIOTIN | |||
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NOD2-FITC | |||
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P-NOD2 | |||
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