General Information |
|
Product |
HIPK3 Peptide |
Description |
Antigenic Blocking Peptide Homeodomain-interacting protein kinase 3 Antibody |
Verified Applications |
Immunodepletion, Immunocompetition |
Peptide Description |
Synthetic peptide taken within amino aci region 860-910 on human Homeodomain-interacting protein kinase 3 protein. |
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|
Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Purification Method |
Immobilized antigen affinity chromatography |
Storage |
-20⁰C for long term storage |
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Competition/Depletion assay |
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Uniprot # |
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Overview |
Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). |
Molecular Function |
ATP binding protein kinase activity protein serine/threonine kinase activity |
Subcellular Location |
Nucleus, cytoplasm |
Expression |
Overexpressed in multidrug resistant cells. Highly expressed in heart and skeletal muscle, and at lower levels in placenta, pancreas, brain, spleen, prostate, thymus, testis, small intestine, colon and leukocytes. Not found in liver and lung. |
Structure |
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily. |
Alternative Nomenclature |
Androgen receptor interacting nuclear protein kinase antibody ANPK antibody DYRK6 antibody Fas-interacting serine/threonine-protein kinase antibody FIST antibody FIST3 antibody Hipk3 antibody homeodomain interacting protein kinase 3 antibody Homolog of protein kinase YAK1 antibody PKY antibody RP24 297H17.5 antibody YAK1 antibody |
Protein information supplied by UniProt.
Product | Note | Status | Price | |
---|---|---|---|---|
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HIPK3-301AP | |||
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HIPK3-BIOTIN | |||
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HIPK3-FITC | |||
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PC-HIPK3 | |||
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