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PDE4B Antibody

Product no.: PD4B-201AP

$320.00

General Information
Product	PDE4B Antibody
Description	Affinity Purified cAMP-specific 3',5'-cyclic phosphodiesterase 4B Antibody N-epitope
Verified Applications	CM, ELISA, ICC, IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide common to all PDE4B subtypes taken near N-terminal
Specificity	This antibody detects all PDE4B proteins, including PDE4B1, PDE4B2, PDE4B3, and a 66 kDa PDE4B variant. It does not cross-react with other PDE family members such as PDE4A, PDE4C. PD4B-201AP may have minor crossreactivity to PDE4D. Antibody PD4B-212AP does not have any cross reactivity with any other PDE family members other than: PDE4B1, PDE4B2, PDE4B3, PDE4B4.
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.68 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Determinant	N-epitope
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:250
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:250
Immunofluorescence	1:250
Immunohistochemistry	1:250
Immunoprecipitation	1:350
Western Blot	1:500-1:1,000
Protein
Uniprot #	Q07343
Overview	Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.
Molecular Function	Hydrolase, 3',5'-cyclic-AMP phosphodiesterase activity, cAMP binding
Expression	Expressed in brain, heart, lung and skeletal muscle.
Alternative Nomenclature	5''-cyclic phosphodiesterase 4B antibody cAMP-specific 3'' antibody cAMP-specific 3',5'-cyclic phosphodiesterase 4B antibody DPDE4 antibody dunce-like phosphodiesterase E4 antibody MGC126529 antibody PDE 4B antibody PDE IVB antibody PDE32 antibody PDE4B5 antibody PDEIVB antibody Phosphodiesterase 4B antibody Phosphodiesterase-4B cAMP-specific (dunce (Drosophila)-homolog) antibody

Protein information supplied by UniProt

Fabgennix PDE4B Antibody has been used in 42 Publications
Kedia, George T., et al. "Expression and Distribution of Phosphodiesterase Isoenzymes in the Human Male Urethra." Urology (2015). PMID25704994	Immunofluorescence, Western Blot; *Human*
Petersen, T. S., et al. "Distribution and function of 3', 5'-Cyclic-AMP phosphodiesterases in the human ovary." Molecular and cellular endocrinology (2015). PMID25578602	Immunohistochemistry; *Human*
Guo, Jiejie, et al. "Etazolate abrogates the lipopolysaccharide (LPS)-induced downregulation of the cAMP/pCREB/BDNF signaling, neuroinflammatory response and depressive-like behavior in mice." Neuroscience 263 (2014): 1-14. PMID24434771	Western Blot; *Mouse*
Zhai, Kui, et al. "Phosphodiesterase types 3 and 4 regulate the phasic contraction of neonatal rat bladder smooth myocytes via distinct mechanisms." Cellular signalling 26.5 (2014): 1001-1010.PMID24463006	Western Blot; *Human*
Hiramoto, Kenichi, et al. "Role of phosphodiesterase 2 in growth and invasion of human malignant melanoma cells." Cellular signalling 26.9 (2014): 1807-1817. PMID24705027	Western Blot; *Rat*
Wang, Zhen-Zhen et al. “RNA Interference-Mediated Phosphodiesterase 4D Splice Variants Knock-down in the Prefrontal Cortex Produces Antidepressant-Like and Cognition-Enhancing Effects.” British Journal of Pharmacology 168.4 (2013): 1001–1014. PMID23003922	Western Blot; *Mouse*
Sanabra, Cristina, Emily M. Johansson, and Guadalupe Mengod. "Critical role for PDE4 subfamilies in the development of experimental autoimmune encephalomyelitis." Journal of chemical neuroanatomy 47 (2013): 96-105. PMID23274837	Immunohistochemistry; *Mouse*
Yougbaré, Issaka, et al. "NCS 613 Exhibits Anti-Inflammatory Effects On Pbmcs From Lupus Patients By Inhibiting P38 MAPK And NF-Κb Signalling Pathways While Reducing Proinflammatory Cytokine Production." Canadian Journal Of Physiology & Pharmacology 91.5 (2013): 353-361. PMID23656347	Immunocytochemistry, Western Blot; *Human*
Haque, Mohammed Z., Paulo S. Caceres, and Pablo A. Ortiz. “β-Adrenergic Receptor Stimulation Increases Surface NKCC2 Expression in Rat Thick Ascending Limbs in a Process Inhibited by Phosphodiesterase 4.” American Journal of Physiology - Renal Physiology 303.9 (2012): F1307–F1314. PMC3518189	Western Blot; *Rat*
Johansson, Emily M., Cristina Sanabra, and Guadalupe Mengod. "Sex‐related differences of cAMP‐specific PDE4B3 mRNA in oligodendrocytes following systemic inflammation." Glia 60.12 (2012): 1815-1825. PMID22848007	Western Blot; *Mouse*

For a complete listing of FabGennix PDE4B publications, please click here.

Publishing research using PD4B-201AP? Please let us know, we can cite the reference in this datasheet.

Could you please provide me with the immunogen sequence for Anti-PDE4B antibody (PD4B-201AP)

If it is not possible to provide me with the immunogen sequence itself, could you please send me the amino acid range that the immunogen is from?

Our PDE4B Antibody (PD4B-201AP), was developed using a recombinant fragment for PDE4B comprising of both UCR1 and UCR2 regions of the long-form variants. The antibody labels all PDE4B variants and has minor cross reactivity to PDE4D. We also have another C-terminal epitope PDE4B selective antibody (PD4B-212AP) that has no cross reactivity to any other PDE4 family members except PDE4B1, PDE4B2, PDE4B3, and PDE4B4.

In addition to these two, we also have antibodies that are selective for PDE4B subtype variants (PDE4B1, PDE4B2, PDE4B3, and PDE4B4) for studying individual variants of the PDE4B family members.

Customer ratings for PDE4B Antibody

Number of ratings: 1
Average rating: 4

Good for western blot
from Anonymous on 12/09/2020

Great results in western blot using rat cell lysate (Mesangial cells). 1/5000 primary antibody dilution for 8 hours.

All incoming ratings are posted by actual shop visitors / webshop customers and their content is checked by the operator by means of a visual inspection.

Accessories

Product

Note

Status

Price

PDE4B Antibody FITC

PD4B-FITC

$375.00 *

PDE4B Antibody BIOTIN

PD4B-BIOTIN

$375.00 *

PDE4B Blocking Peptide

P-PD4B

$155.00 *

PDE4B Positive Control

PC-PD4B

$220.00 *

PD4B-212AP PDE4B Antibody $320.00 *	PD4B1-261AP PDE4B1 Antibody $320.00 *	PD4B2-251AP PDE4B2 Antibody $320.00 *
PD4B3-221AP PDE4B3 Antibody $320.00 *	PD4B4-231AP PDE4B4 Antibody $320.00 *

PDE4A Antibody $375.00 *	PDE4A5 Antibody $320.00 *	PDE4B1 Antibody $320.00 *
PDE4A1 Antibody $320.00 *	PDE4A10 Antibody $320.00 *

General Information
Product	Phospho Lyn Antibody Affinity Purified
Description	Affinity Purified Tyrosine-protein kinase Lyn isoform A Antibody
Verified Applications	ELISA, WB
Host	Rabbit
Immunogen	Phosphorylated synthetic peptide taken within amino acid region 425-525 on human Lyn protein. Phospho Y 491.
Accession #	NCBI: NP_002341
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.55-0.75 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:10,000
ELISA	1:10,000
Western Blot	1:500
Protein
Uniprot #	P07948
Overview	Non-receptor tyrosine-protein kinase that plays role in regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents
Molecular Function	Kinase, Transferase, Tyrosine-protein kinase
Subcellular Location	Cell membrane, Cytoplasm, Golgi apparatus, Membrane, Nucleus
Expression	monocytes,placenta,fetal brain, lung, liver,kidney and epidermoid, hematopoietic, and neuronal cells,also primary neuroblastoma tumors
Structure	Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily
Alternative Nomenclature	AA407514 antibody EC 2.7.10.2 antibody FLJ26625 antibody Hck 2 antibody JTK 8 antibody Lck/Yes related novel protein tyrosine kinase antibody LYN antibody LYN proto oncogene, Src family tyrosine kinase antibody ONCOGENE LYN antibody p53Lyn antibody p56Lyn antibody Tyrosine protein kinase LYN antibody V yes 1 Yamaguchi sarcoma viral related oncogene homolog antibody

General Information
Product	CACNB2 Antibody Affinity Purified
Description	Affinity Purified Voltage dependent L-type calcium channel subunit beta-2 Antibody
Verified Applications	ELISA, IMM, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide taken within amino acid region 500-600 on rat voltage-dependent L-type calcium channel subunit beta-2 protein
Accession #	NCBI: NP_446303
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.6 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:10,000
ELISA	1:10,000
Immunoprecipitation	1:200
Western Blot	1:500
Protein
Uniprot #	Q8VGC3
Overview	The beta subunit of voltage-dependent calcium channel which contributes to calcium channel function by increasing peak calcium current, shifting the voltage dependencies fo activation and inactivation, modulating G-protein inhibition and controllin the alpha-1 subunit membrane targeting.
Molecular Function	Calcium; Transport; Ion transport
Subcellular Location	Cell membrane; Sacrolemma; Peripheral membrane protein, cytoplasmic side
Expression	Heart and brain. Lower expression in lung.
Structure	L-type channel is composed of four subunits: alpha-1, alpha-2, beta and gamma.
Alternative Nomenclature	AW060387 antibody Ca(V) beta 2 antibody CAB2 antibody CAVB2 antibody Cavbeta2 antibody Cchb2 antibody Lambert Eaton Myasthenic syndrome antigen antibody MYSB antibody

General Information
Product	Chimaerin beta 3 Antibody
Description	Affinity Purified Beta-Chimaerin isoform 3 Antibody
Verified Applications	ELISA, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide taken within amino acid region 1-100 on human beta-chimaerin isoform 3 protein.
Accession #	NCBI: NP_001279998.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.68-0.71 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:10,000
ELISA	1:10,000
Immunoprecipitation	1:200
Western Blot	1:500
Protein
Uniprot #	P52757
Overview	GTPase-activating protein for p21-rac. May play role in progression from low-grade to high-grade tumors.
Molecular Function	Metal binding; Zinc
Subcellular Location	Membrane
Expression	Brain, pancreas, heart, placenta. Weakly expressed in kidney and liver.
Structure	Contains 1 phorbol-ester/DAG-type zinc finger; 1 Rho-GAP domain; 1 SH2 domain.
Alternative Nomenclature	ARHGAP3 antibody BCH antibody Beta chimerin antibody Chimaerin3 antibody CHN3 antibody MGC138360 antibody Rho GTPase activating protein 3 antibody RHOGAP3 antibody

General Information
Product	Cytohesin 4 Antibody Affinity Purified
Description	Affinity Purified Cytohesin 4 Antibody
Verified Applications	ELISA, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide taken within amino acid region 300-362 on human Cytohesin 4 protein.
Accession #	GenBank: AAH41161.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.61 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:10,000
ELISA	1:10,000
Western Blot	1:500
Protein
Uniprot #	Q9UIA0
Overview	Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP.
Molecular Function	ARF guanyl-nucleotide exchange factor activity, lipid binding
Subcellular Location	Cell membrane; Peripheral membrane protein
Expression	Expressed predominantly in peripheral blood leukocytes.
Structure	Contains 1 PH domain, Contains 1 SEC7 domain
Alternative Nomenclature	AI467541 antibody CYT4 antibody Cyth4 antibody Cytohesin 4 antibody DJ63G5.1 antibody FLJ00017 antibody PH antibody PH, SEC7 and coiled coil domain containing protein 4 antibody Pleckstrin homology, SEC7, AND coiled coil domains protein 4 antibody Pscd4 antibody RGD1564842 antibody SEC7 and coiled-coil domain-containing protein 4 antibody

General Information
Product	DEK Antibody
Description	Affinity Purified DEK Antibody
Verified Applications	ELISA, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Monkey, Mouse, Rat Predicted: Cat, Cow
Immunogen	Synthetic peptide taken within residues corresponding to a region within amino acids 324-373 of human DEK. Region: ELKETIKKLL ASANLEEVTM KQICKKVYEN YPTYDLTERK DFIKTTVKEL
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.65 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20°C for long term storage
Application Protocol
Dot blot	1:10,000
ELISA	1:10,000
Immunohistochemistry	1:50-1:150
Immunoprecipitation	1:200
Western Blot	1:500-1:750 Predicted molecular weight: 43 kDa
Protein
Uniprot #	P35659
Overview	Involved in chromatin organization
Molecular Function	Chromatin regulator; DNA-binding
Subcellular Location	Nucleus
Expression	Ubiquitous
Structure	Contains 1 SAP domain
Alternative Nomenclature	D6S231E antibody

General Information
Product	GPCR GPR40 Antibody
Description	Affinity Purified FFAR1 protein Antibody
Verified Applications	ELISA, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide taken within amino acid region 150-200 on human FFA1 protein.
Accession #	GenBank: AAI20944.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.58-0.59 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:10,000
ELISA	1:10,000
Western Blot	1:500
Protein
Uniprot #	Q0IJ71
Molecular Function	G-protein coupled receptor activity
Subcellular Location	Integral component of membrane
Alternative Nomenclature	FFA1R antibody Free fatty acid receptor 1 antibody G protein coupled receptor 40 antibody GPR40 antibody

FFAR2-201AP GPCR GPR43 / FFAR2 Antibody $285.00 *	FFAR2-212AP GPCR GPR43 / FFAR2 Antibody $285.00 *	FFAR3-301AP FFAR3 Antibody $285.00 *
FFAR4-401AP GPCR GPR120 Antibody $285.00 *

General Information
Product	Pan PDE3A Antibody Affinity Purified
Description	Affinity Purified cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform 1 Antibody
Verified Applications	CM, ELISA, ICC, IHC, IF, WB
Host	Goat
Species Cross Reactivity	Human, Monkey, Mouse, Rat, Xenopus
Immunogen	Synthetic peptide selective only for PDE3A variants
Accession #	NCBI: NP_000912.3
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.72 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:250
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:250
Immunofluorescence	1:250
Immunohistochemistry	1:250
Immunoprecipitation	1:200
Western Blot	1:500
Protein
Uniprot #	Q14432
Overview	Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.
Molecular Function	Hydrolase, 3', 5'-cyclic-GAP phosphodiesterase activity, cAMP binding
Subcellular Location	Membrane; Multi-pass membrane protein
Alternative Nomenclature	cAMP phosphodiesterase myocardial cGMP inhibited antibody CGI-PDE A antibody Cyclic GMP-inhibited phosphodiesterase A antibody Human cGMP inhibited cAMP phosphodiesterase mRNA antibody PDE 3A antibody Phosphodiesterase 3A antibody Phosphodiesterase 3A cGMP inhibited antibody

General Information
Product	PDE3A Antibody
Description	Affinity Purified cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform 1 Antibody
Verified Applications	ELISA, FRET, ICC/IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Monkey, Mouse, Rat, Xenopus
Immunogen	Synthetic peptide selective only for PDE3A variants.
Accession #	NCBI: NP_000912.3
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.719 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:250
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:250
Immunofluorescence	1:250
Immunohistochemistry	1:250
Immunoprecipitation	1:200
Western Blot	1:500
Protein
Uniprot #	Q14432
Overview	Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.
Molecular Function	Hydrolase, 3', 5'-cyclic-GAP phosphodiesterase activity, cAMP binding
Subcellular Location	Membrane; Multi-pass membrane protein
Alternative Nomenclature	cAMP phosphodiesterase myocardial cGMP inhibited antibody CGI PDE A antibody CGI PDE antibody Cyclic GMP-inhibited phosphodiesterase A antibody Human cGMP inhibited cAMP phosphodiesterase mRNA antibody PDE 3A antibody Phosphodiesterase 3A antibody Phosphodiesterase 3A cGMP inhibited antibody

Home page Primary Antibodies Signal Transduction Second Messengers cAMP PDE4B Antibody

Home page Primary Antibodies Signal Transduction Second Messengers cAMP PDE4B Antibody

Home page Primary Antibodies Protein Kinases Tyrosine Kinases Src Family Phospho-Lyn Antibody

Home page Primary Antibodies Neuroscience Neurotransmission CACNB2 Antibody

Home page Primary Antibodies Signal Transduction G-Protein Coupled Receptors Chimaerin beta 3 Antibody

Home page Primary Antibodies Signal Transduction Regulation Cytohesin 4 Antibody

Home page Primary Antibodies Epigenetics Transcription DEK Antibody

Home page Primary Antibodies Signal Transduction G-Protein Coupled Receptors GPCR GPR40 Antibody

Home page Primary Antibodies Signal Transduction Second Messengers cAMP PDE3A Antibody

Home page Primary Antibodies Signal Transduction Phosphodiesterases PDE3A Antibody

PDE4B Antibody

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