General Information

Product

FEL D1 Major Allergen I Polypeptide Chain 1 Antibody Affinity Purified

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Cat

Immunogen

Synthetic peptide taken within amino acid region 1-50 on feline Major Cat Allergen I polypeptide chain 1.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P30438

Overview

Causes an allergic reaction in human. Binds to IgE. Major allergen produced by the domestic cat. Implicated as an asthma-inducing agent in human. This protein is sticky and easily adheres to walls, carpet, clothing, furniture and bedding.

Subcellular Location

Secreted; Extracellular region

Expression

Saliva and sebaceous glands.

Structure

Heterotetramer composed of two non-covalently linked disulfide-linked heterodimer of chains 1 and 2.

Alternative Nomenclature

CH1, Fel D1, AG4, Allergen Cat-1, Allergen D I-A, Allergen FDI, Allergen Fel Di, Allregen: Fel d 1-A

General Information

Product

FEL D1 Major Allergen I Polypeptide Chain 1 Antibody Affinity Purified  C-epitope

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Cat

Immunogen

Synthetic peptide taken within amino acid region 42-88 on feline Major Cat Allergen I polypeptide chain 1.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P30438

Overview

Causes an allergic reaction in human. Binds to IgE. Major allergen produced by the domestic cat. Implicated as an asthma-inducing agent in human. This protein is sticky and easily adheres to walls, carpet, clothing, furniture and bedding.

Subcellular Location

Secreted; Extracellular region

Expression

Saliva and sebaceous glands.

Structure

Heterotetramer composed of two non-covalently linked disulfide-linked heterodimer of chains 1 and 2.

Alternative Nomenclature

CH1, Fel D1, AG4, Allergen Cat-1, Allergen D I-A, Allergen FDI, Allergen Fel Di, Allregen: Fel d 1-A

General Information

Product

TdT Antibody

Description

Affinity Purified DNA nucleotidylexotransferase Antibody Extreme C-epitope

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Chicken, Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 459-509 on human Terminal deoxynucleotidyltransferase protein.

Accession #

NCBI:  NP_004079

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.6 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

Extreme C-epitope

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:250

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

Western Blot

1:1,000

Protein

Uniprot #

P04053

Overview

Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.

Molecular Function

Nucleotidyltransferase, Transferase, DNA binding

Subcellular Location

Nucleus

Structure

Interacts with PRP19 and DNTTIP1. Forms a ternary complex with DNTTIP2 and core histone. Released from this complex by PCNA.

Alternative Nomenclature

Deoxynucleotidyltransferase terminal antibody
DNA nucleotidylexotransferase antibody
DNTT antibody
Nucleosidetriphosphate DNA deoxynucleotidylexotransferase antibody
TDT antibody
Terminal addition enzyme antibody
Terminal deoxynucleotidyltransferase antibody
Terminal transferase antibody

General Information

Product

TdT Antibody

Description

Affinity Purified DNA nucleotidylexotransferase Antibody C-epitope

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Chicken, Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 450-500 on human Terminal deoxynucleotidyltransferase protein.

Accession #

NCBI:  NP_004079

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.6 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:250

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

Western Blot

1:1,000. Detects a band of approximately 58 kDa.

Protein

Uniprot #

P04053

Overview

Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.

Molecular Function

Nucleotidyltransferase, Transferase, DNA binding

Subcellular Location

Nucleus

Structure

Interacts with PRP19 and DNTTIP1. Forms a ternary complex with DNTTIP2 and core histone. Released from this complex by PCNA.

Alternative Nomenclature

Deoxynucleotidyltransferase terminal antibody
DNA nucleotidylexotransferase antibody
DNTT antibody
Nucleosidetriphosphate DNA deoxynucleotidylexotransferase antibody
TDT antibody
Terminal addition enzyme antibody
Terminal deoxynucleotidyltransferase antibody
Terminal transferase antibody

General Information

Product

Lck Antibody

Description

Affinity Purified Lymphocyte cell-specific protein-tyrosine kinase Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 500-539 on human Lymphocyte cell-specific protein-tyrosine kinase.

Accession #

GenBank: AAH13200.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P06239

Overview

Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex.

Molecular Function

Kinase, Transferase, Tyrosine-protein kinase

Subcellular Location

Cell membrane, Cytoplasm, Membrane

Expression

Expressed specifically in lymphoid cells.

Structure

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.

Contains 1 protein kinase domain.

Contains 1 SH2 domain.

Contains 1 SH3 domain.

Alternative Nomenclature

IMD22 antibody

LCK antibody

Lck p56 antibody

LCK proto-oncogene, Src family tyrosine kinase antibody

Leukocyte C-terminal Src kinase antibody

LSK antibody

Lymphocyte cell specific protein tyrosine kinase antibody

Membrane associated protein tyrosine kinase antibody

Oncogene lck antibody

p56(LSTRA) protein tyrosine kinase antibody

p56-LCK antibody

pp58 lck antibody

Protein YT16 antibody

Protooncogene tyrosine protein kinase LCK antibody

T lymphocyte specific protein tyrosine kinase p56lck antibody

Tyrosine-protein kinase Lck antibody

YT 16 antibody

General Information

Product

PD-L2 Antibody

Description

Affinity Purified Programmed cell death 1 ligand 2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Predicted: Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 115-165 on human Programmed cell death 1 ligand 2 protein.

Accession #

NCBI:  NP_079515

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q9BQ51

Overview

Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.

Molecular Function

Receptor

Subcellular Location

Isoform 3 : Secreted

Isoform 2 : Endomembrane system, Single-pass type I membrane protein

Isoform 1 : Cell membrane, Single-pass type I membrane protein

Expression

Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus.

Structure

Belongs to the immunoglobulin superfamily. BTN/MOG family.

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Alternative Nomenclature

B7 dendritic cell molecule antibody

B7-DC antibody

Btdc antibody

Butyrophilin B7 DC antibody

CD 273 antibody

PD 1 ligand 2 antibody

PD-L2 antibody

PDCD 1 ligand 2 antibody

PDCD1L2 antibody

Pdcd1lg2 antibody

Programmed cell death 1 ligand 2 antibody

Programmed death ligand 2 antibody

General Information

Product

IL18RAP Antibody

Description

Affinity Purified Interleukin-18 receptor accessory protein Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Rat

Predicted: Mouse

Immunogen

Synthetic peptide taken within amino acid region 500-550 on human Interleukin-18 receptor accessory protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

O95256

Overview

Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation.

Molecular Function

Receptor activity

Subcellular Location

Membrane, Single-pass type I membrane protein

Expression

Strongly expressed in peripheral blood leukocytes, spleen, lung, and, to a lesser extent, in colon, but not in any other tissue tested. Strongly expressed in T-cells polarized with IL-12. Specifically coexpressed with IL18R1 in Th1 cells.

Structure

Belongs to the interleukin-1 receptor family.

Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 TIR domain.

Alternative Nomenclature

IL18RAP antibody

Accessory protein like antibody

AcPL antibody

CD218 antigen-like family member B antibody

CDw218b antibody

IL-18R-beta antibody

IL-18RAcP antibody

IL-18Rbeta antibody

IL-1R accessory protein-like antibody

IL-1R7 antibody

IL-1RAcPL antibody

IL18RAP antibody

IL18Rbeta antibody

Interleukin 18 receptor accessory protein antibody

Interleukin-1 receptor 7 antibody

Interleukin-18 receptor beta antibody