General Information |
|
Product |
WWOX 1/4 Antibody FITC-Conjugated |
Description |
FITC-Conjugated WW domain-containing Oxidoreductase isoform 1 Antibody |
Verified Applications |
ELISA, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse |
Immunogen |
Synthetic peptide corresponding to unique amino acid sequence on WWOX 1 and WWOX4 protein. |
Accession # |
NCBI: NP_057457.1 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.62 µg/µl in antibody stabilization buffer |
Form |
FITC-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
DB |
1:10,000-1:100,000 |
ELISA |
1:10,000-1:100,000 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm. |
Molecular Function |
Coenzyme binding; protein dimerization activity; cofactor binding; |
Subcellular Location |
Cytoplasm. Nucleus. Mitochondrion. Golgi apparatus |
Expression |
Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines. |
Structure |
Interacts with TP53, p73/TP73 and MAPK8. Interacts with MAPT/TAU, RUNX2 and HYAL2 (By similarity). Forms a ternary complex with TP53 and MDM2. Interacts with ERBB4, LITAF and WBP1. Interacts with DVL1, DVL2 and DVL3. May interact with FAM189B and SCOTIN. |
Alternative Nomenclature |
D16S432E antibody FOR antibody FOR II protein antibody FRA16D antibody fragile 16D oxido reductase antibody fragile site FRA16D oxidoreductase antibody HHCMA56 antibody PRO0128 antibody putative oxidoreductase antibody WW domain-containing oxidoreductase antibody WW domain-containing protein WWOX antibody WWOX antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
WWOX1-101AP | |||
|
P-WWOX1 | |||
|
WWOX1-BIOTIN | |||
|
PC-WWOX1 | |||
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