Ephrin Receptor A7 Blocking Peptide

General Information

Product

Ephrin Receptor A7 Peptide

Description

Antigenic Blocking Peptide Ephrin type-A receptor 7 isoform 1 precursor Antibody

Verified Applications

Immunocompetition, Immunodepletion

Peptide Description

Synthetic peptide corresponding taken within amino acid region 500-550 on human Ephrin type-A receptor 7 protein.

Accession #

NCBI:  NP_004431

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Storage

-20⁰C for long term storage

Application Protocol

Competition/Depletion assay

Refer to competition assay protocol

Protein

Uniprot #

Q15375

Overview

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. 

Molecular Function

Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase

Subcellular Location

Cell membrane, Single-pass type 1 membrane protein

Expression

Widely Expressed

Structure

Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. Interacts (via PDZ-binding motif) with GRIP1 and PICK1.

Alternative Nomenclature

Cek 11 antibody

Developmental kinase 1 antibody

EBK antibody

EHK3 antibody

EK11 antibody

Embryonic brain kinase antibody

Eph homology kinase 3 antibody

Eph receptor A7 antibody

EPH-like kinase 11 antibody

EphA7 antibody

Ephrin type-A receptor 7 antibody

hEK11 antibody

MDK 1 antibody

Receptor protein tyrosine kinase HEK 11 antibody

Tyrosine protein kinase receptor EHK 3 antibody