Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
Molecular Function
calcium-dependent protein binding
calmodulin binding
phosphatidylinositol-4,5-bisphosphate binding
potassium:proton antiporter activity
protein binding, bridging
protein complex scaffold
protein phosphatase 2B binding
sodium:proton antiporter activity
Subcellular Location
Membrane; Multi-pass membrane protein
Endoplasmic reticulum membrane; Multi-pass membrane protein