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General Information
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Product
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VEGFR1 Positive Control
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Description
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Western Blot Positive Control Vascular Endothelial Growth Factor Receptor 1
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Verified Applications
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WB
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Immunogen
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Purified Protein
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Physical Properties
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Quantity
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5 Applications
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Volume
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Inquire
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Form
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Western Blot Positive Control
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| Concentration |
Empircally set for optimal signal-to-noise-ratio. |
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Storage
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-20⁰C for long term storage
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| Storage Buffer |
Preapred in SDS-sample buffer |
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Application Protocol
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Western Blot
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1:2,500-1:5,000
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Protein
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Uniprot #
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P17948
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Overview
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Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood.
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Molecular Function
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Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase
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Subcellular Location
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Isoform 1 :Cell membrane; Single-pass type I membrane protein
Endosome
Note: Autophosphorylation promotes ubiquitination and endocytosis.
Isoform 2 :Secreted
Isoform 3 :Secreted
Isoform 4 :Secreted
Isoform 5 :Cytoplasm
Isoform 6 :Cytoplasm
Isoform 7 :Cytoplasm
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Expression
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Detected in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. Isoform 2 is strongly expressed in placenta. Isoform 3 is expressed in corneal epithelial cells (at protein level). Isoform 3 is expressed in vascular smooth muscle cells (VSMC).
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Structure
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The second and third Ig-like C2-type (immunoglobulin-like) domains are sufficient for VEGFA binding. Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. Contains 7 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 protein kinase domain.
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Alternative Nomenclature
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EC 2.7.10.1 antibody
FLT antibody
FLT1 antibody
Fms like tyrosine kinase 1 antibody
Fms related tyrosine kinase 1 antibody
Fms related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) antibody
FRT antibody
Soluble VEGF receptor 1 14 antibody
Soluble VEGFR1 variant 2 antibody
Soluble VEGFR1 variant 21 antibody
Tyrosine protein kinase FRT antibody
Tyrosine protein kinase receptor FLT antibody
Vascular endothelial growth factor vascular permeability factor receptor antibody
Vascular permeability factor receptor 1 antibody
VEGFR1 antibody
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VEGFR1 Antibody
VEGFR1 Antibody FITC
VEGFR1 Antibody BIOTIN
VEGFR1 Blocking Peptide
