General Information

Product

AIM2 Antibody

Description

Affinity Purified Interferon-inducible protein AIM2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Immunogen

Synthetic peptide taken within amino acid region 240-340 on human AIM2 protein.

Accession #

NCBI:  NP_004824

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.58 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O14862

Overview

Innate immune response recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages.  Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.

Molecular Function

Apoptosis, Immunity, Inflammatory response, Innate Immunity

Expression

Expressed in spleen, small intestine, peripheral blood leukocytes and testis. 

Structure

Self-associates; forms homodimers in response to cytosolic dsDNA and the dsDNA serves as oligomerization platform.

Alternative Nomenclature

Absent in melanoma 2 antibody

PYHIN4 antibody

General Information

Product

Axin 2 Antibody

Description

Affinity Purified Axis Inhibition Protein 2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Immunogen

Synthetic peptide taken within amino acid region 800-843 on human Axin 2 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9Y2T1

Overview

Inhibitor of Wnt signaling pathway.  Down-regulates beta-catenin.

Molecular Function

Developmental Protein; Wnt signaling pathway

Subcellular Location

Cytoplasm

Expression

Brain and lymphoblast

Structure

Contains 1 DIX domain and 1 RGS domain

Alternative Nomenclature

Axil antibody

Axin like protein antibody

Axis inhibition protein 2 antibody

Conductin antibody

General Information

Product

Axl Antibody

Description

Affinity Purified AXL receptor tyrosine kinase UFO isoform 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 840-880 on mouse AXL protein. The peptide was post translationally modified to acheive proper orientation and antigenicity.

Accession #

NCBI:  NP_033491

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Western Blot

1:500

Protein

Uniprot #

Q00993

Overview

Receptor tyrosine kinase that transduces signals from the ECM into cytoplasm by binding growth factor GAS6. Regulates survival, proliferation, migration and differentiation.

Molecular Function

ATP-binding, Nucleotide binding, Kinase, Receptor, Transferase, Tyrosine-protein kinase, Immunity Differentation and Innate Immunity.

Subcellular Location

Cell membrane; Single-pass type II membrane protein.

Expression

Developing tissues in late embryogenesis. In cells forming organ capsules as well as in connective tissue structures in adult.

Structure

Heterodimer and heterotetramer with ligand GAS6.

Alternative Nomenclature

Adhesion related kinase 

Ark 

Tyro7 

Tyrosine protein kinase receptor UFO 

General Information

Product

FYN Antibody

Description

Affinity Purified Fyn Tyrosine Kinase Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 240-290 on human Fyn protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q96AE4

Molecular Function

Developmental protein, Kinase, Transferase, Tyrosine-protein kinase

Subcellular Location

Cytoplasm; Nucleus; Cell membrane

Expression

Isoform 1 is expressed in the brain, and Isoform 2 is expressed in cells of hemopoietic lineages.

Structure

Interacts with PIK3R1,PRMT8,FYB, PAG1, SH2D1A, CD79A.  Also interacts with HEV ORF3 protein, ITCH, RUNX3, KIT, PTK1/FAK1, CAV1, UNC119 and EPHA8.

Alternative Nomenclature

C syn protooncogene antibody

Fyn antibody

FYN oncogene related to SRC FGR YES antibody

OKT3 induced calcium influx regulator antibody

P59 FYN antibody

Proto oncogene tyrosine protein kinase fyn antibody

Proto-oncogene c-Fyn antibody

Proto-oncogene Syn antibody

SLK antibody

Src yes related novel gene antibody

Src-like kinase antibody

SYN antibody

Tyrosine kinase p59fyn(T) antibody

Tyrosine-protein kinase Fyn antibody

General Information

Product

G0/G1 switch 2 Antibody

Description

Affinity Purified Lymphocyte G0/G1 Switch protein 2 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 78-103 on mouse G0S2-like protein. The peptide was covalently modified to achieve desired antigenicity and conjugated to a carrier protein.

Sequence:

ALLAGGKAQEATLCSRALSLRQHAS

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.51-0.54 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Dot Blot

1:10,000

ELISA

1:10,000

Western Blot

1:500 Predicted molecular weight: 11 kDa.

Protein

Uniprot #

Q68515

Subcellular Location

Mitochondrion

Structure

Interacts directly with BCL2; which prevents the formation of the anti-apoptotic BAX-BCL2 complex.

Alternative Nomenclature

G0/G1 switch regulatory protein 2 antibody

OTTHUMP00000034644 antibody

Putative lymphocyte G0/G1 switch protein 2 antibody

RP1 28O10.2 antibody

General Information

Product

GADD45B Antibody

Description

Affinity Purified Negative growth regulatory protein Antibody

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 100-160 on mouse GADD45b protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.6 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P22339

Overview

Acts in the regulation of growth and apoptosis.  Also mediates the activation of stress-responsive MTK1/MEKK4 MAPKKK.

Molecular Function

Developmental protein

Subcellular Location

Cytoplasm

Expression

Expressed in myeloid precursor enriched BM cells

Structure

Interacts with GADD45GIP2

Alternative Nomenclature

GADD45 Beta antibody

Growth arrest and DNA damage-inducible gene GADD45, beta antibody

MYD118, mouse, homolog of antibody

Myeloid differentiation primary response protein MyD118 antibody

Negative growth regulatory protein MyD118 antibody

General Information

Product

ErbB 2 Antibody

Description

Affinity Purified Receptor tyrosine-protein kinase erB-2 isoform b Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 130-180 receptor tyrosine-protein kinase erbB-2 protein.

Accession #

NCBI:  NP_001005862.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65-1.25 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P04626

Overview

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs).

Molecular Function

Activator, Kinase, Receptor, Transferase, Tyrosine-protein kinase

Subcellular Location

Isoform 1: Cell membrane; Single-pass type I membrane protein, Cytoplasm>perinuclear region, Nucleus. Isoform 2: Cytoplasm, Nucleus. Isoform 3: Cytoplasm, Nucleus.

Expression

Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.

Structure

Homodimer. Heterodimer with EGFR, ERBB3 and ERBB4. Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts with PRKCABP and PLXNB1. Interacts (when phosphorylated on Tyr-1248) with MEMO1. Interacts with MUC1; the interaction is enhanced by hereguline (HRG).

Alternative Nomenclature

Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody

c erb B2 antibody

CD340 antibody

cneu antibody

Erb B2 antibody

Erythroblastosis Virus antibody

HER 2 antibody

Herstatin antibody

Metastatic lymph node gene 19 protein antibody

MLN 19 antibody

NEU proto oncogene antibody

Neuro Glioblastoma Derived Oncogene Homolog antibody

NGL antibody

p185 ErbB2 antibody

Proto-oncogene Neu antibody

Receptor Protein Tyrosine Kinase ErbB2 Precursor antibody

TKR1 antibody

verbb2 antibody

General Information

Product

ErbB 2 Antibody

Description

Affinity Purified Receptor tyrosine-protein kinase erB-2 isoform a Antibody N-epitope

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Predicted: Rat

Immunogen

Synthetic peptide taken within amino acid region 1125-1175 receptor tyrosine-protein kinase erbB-2 protein.

Accession #

NCBI:  NP_004439.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65-1.25 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Determinant

N-epitope

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P04626

Overview

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs).

Molecular Function

Activator, Kinase, Receptor, Transferase, Tyrosine-protein kinase

Subcellular Location

Isoform 1: Cell membrane; Single-pass type I membrane protein, Cytoplasm>perinuclear region, Nucleus. Isoform 2: Cytoplasm, Nucleus. Isoform 3: Cytoplasm, Nucleus.

Expression

Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.

Structure

Homodimer. Heterodimer with EGFR, ERBB3 and ERBB4. Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts with PRKCABP and PLXNB1. Interacts (when phosphorylated on Tyr-1248) with MEMO1. Interacts with MUC1; the interaction is enhanced by heregulin (HRG).

Alternative Nomenclature

Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody

CD340 antibody

CerbB2 antibody

cneu antibody

Erb B2 antibody

erbb2 antibody

Erythroblastosis Virus antibody

HER 2 antibody

Herstatin antibody

Metastatic lymph node gene 19 protein antibody

MLN 19 antibody

NEU antibody

Neuro Glioblastoma Derived Oncogene Homolog antibody

NGL antibody

p185 ErbB2 antibody

Proto-oncogene Neu antibody

Receptor Protein Tyrosine Kinase ErbB2 Precursor antibody

Tyrosine kinase-type cell surface receptor HER2 antibody

V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) antibody

v erb b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) antibody

General Information

Product

ErbB 2 Antibody

Description

Affinity Purified Receptor tyrosine-protein kinase erB-2 isoform A Antibody C-epitope

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Predicted: Rat

Immunogen

Synthetic peptide taken within amino acid region 1205-1255 receptor tyrosine-protein kinase erbB-2 protein.

Accession #

NCBI:  NP_004439.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65-1.25 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P04626

Overview

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs).

Molecular Function

Activator, Kinase, Receptor, Transferase, Tyrosine-protein kinase

Subcellular Location

Isoform 1: Cell membrane; Single-pass type I membrane protein, Cytoplasm>perinuclear region, Nucleus. Isoform 2: Cytoplasm, Nucleus. Isoform 3: Cytoplasm, Nucleus.

Expression

Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.

Structure

Homodimer. Heterodimer with EGFR, ERBB3 and ERBB4. Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts with PRKCABP and PLXNB1. Interacts (when phosphorylated on Tyr-1248) with MEMO1. Interacts with MUC1; the interaction is enhanced by heregulin (HRG).

Alternative Nomenclature

Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody

CD340 antibody

CerbB2 antibody

cneu antibody

Erb B2 antibody

erbb2 antibody

Erythroblastosis Virus antibody

HER 2 antibody

Herstatin antibody

Metastatic lymph node gene 19 protein antibody

MLN 19 antibody

NEU antibody

Neuro Glioblastoma Derived Oncogene Homolog antibody

NGL antibody

p185 ErbB2 antibody

Proto-oncogene Neu antibody

Receptor Protein Tyrosine Kinase ErbB2 Precursor antibody

Tyrosine kinase-type cell surface receptor HER2 antibody

V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) antibody

v erb b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) antibody

General Information

Product

ErbB 4 Antibody

Description

Affinity Purified Receptor tyrosine-protein kinase erB-4 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1225-1275 on human Receptor tyrosine-protein kinase erbB-4.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65-1.25 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q15303

Overview

Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis.

Molecular Function

ATP binding; epidermal growth factor receptor binding; protein homodimerization activity; receptor signaling protein tyrosine kinase activity; transcription regulatory region DNA binding; transmembrane receptor protein tyrosine kinase activity

Subcellular Location

Cell membrane; Single-pass type I membrane protein. ERBB4 intracellular domain: Nucleus; Mitochondrion

Expression

Expressed at highest levels in brain, heart, kidney, in addition to skeletal muscle, parathyroid, cerebellum, pituitary, spleen, testis and breast. Lower levels in thymus, lung, salivary gland, and pancreas. Isoform JM-A CYT-1 and isoform JM-B CYT-1 are expressed in cerebellum, but only the isoform JM-B is expressed in the heart.

Structure

Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. 

Contains 1 protein kinase domain.

Alternative Nomenclature

4ICD antibody

ALS19 antibody

E4ICD antibody

EC 2.7.10.1 antibody

ERBB4 antibody

HER4 antibody

Mer4 antibody

MGC138404 antibody

Oncogene ERBB4 antibody

p180erbB4 antibody

Proto-oncogene-like protein c-ErbB-4 antibody

Receptor tyrosine protein kinase erbB 4 antibody

s80HER4 antibody

Tyrosine kinase type cell surface receptor HER4 antibodyv erb a avian erythroblastic leukemia viral oncogene homolog like 4 antibody