General Information

Product

C11orf1 Antibody

Description

Affinity Purified Chromosome 11 open reading frame 1 Antibody Mid-Region

Verified Applications

ELISA

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Mid-region epitope synthetic peptide taken within aino acid region 50-100 on human C11orf1 protein

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65-0.67 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

Mid-Region

Storage

-20⁰C for long term storage

Application Protocol

DB

1:15,000-1:20,000

ELISA

1:15,000-1:20,000

Protein

Uniprot #

Q9H5F2

Molecular Function

Nucleus

Alternative Nomenclature

C11orf1 antibody

Chromosome 11 open reading frame 1 antibody

UPF0686 protein

General Information

Product

C11orf1 Antibody

Description

Affinity Purified Chromosome 11 open reading frame 1 Antibody C-epitope

Verified Applications

ELISA

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

C-epitope synthetic peptide taken within amino acid region 100-150 on human C11orf1 protein

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65-0.67 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:15,000-1:20,000

ELISA

1:15,000-1:20,000

Protein

Uniprot #

Q9H5F2

Molecular Function

Nucleus

Alternative Nomenclature

C11orf1 antibody

Chromosome 11 open reading frame 1 antibody

UPF0686 protein

General Information

Product

C1ORF177 Antibody

Description

Affinity Purified Lymphocyte expansion molecule Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse

Immunogen

Synthetic peptide taken within amino acid region 360-410 on mouse lyhmpocyte expansion molecule.

Accession #

GenBank:  AKD95359

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

A0A0F6T326

Alternative Nomenclature

Chromosome 1 open reading frame 177 antibody

FLJ40201 antibody

Hypothetical protein LOC163747 antibody

Uncharacterized protein C1orf177  antibody Lymphocyte expansion molecule antibody

General Information

Product

MOR1 Antibody

Description

Affinity Purified Mu-type opioid receptor isoform MOR-1i Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 405-455 on human Mu-type opiod receptor isoform MOR-1i protein.

Accession #

NCBI:  NP_001272453

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P35372

Overview

Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors.

Molecular Function

G-protein coupled receptor, Receptor, Transducer

Subcellular Location

Cell membrane > Multi-pass membrane protein. Isoform 12: Cytoplasm

Expression

Expressed in brain. Isoform 16 and isoform 17 are detected in brain.

Structure

Forms homooligomers and heterooligomers with other GPCRs, such as OPRD1, OPRK1, OPRL1, NPFFR2, ADRA2A, SSTR2, CNR1 and CCR5 (probably in dimeric forms). Interacts with PPL; the interaction disrupts agonist-mediated G-protein activation. Interacts (via C-terminus) with DNAJB4 (via C-terminus). Interacts with calmodulin; the interaction inhibits the constitutive activity of OPRM1; it abolishes basal and attenuates agonist-stimulated G-protein coupling. Interacts with FLNA, PLD2, RANBP9 and WLS. Interacts with GPM6A, RTP4, SYP, GNAS, RGS9, RGS17, RGS20, RGS4, PPP1R9B and HINT1.

Alternative Nomenclature

hMOP antibody

LMOR antibody

M-OR-1 antibody

MOP antibody

MOR antibody

MOR-1 antibody

Mu opiate receptor antibody

Mu opioid receptor antibody

Opioid receptor mu 1 antibody

OPRM antibody

OPRM1 antibody

General Information

Product

Syncytin A Antibody

Description

Affinity Purified Envelope glycoprotein syncytin-A Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 180-230 on rat Envelope glycoprotein syncytin-A protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q5G5D4

Overview

This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5 (PubMed:10708449, PubMed:12050356, PubMed:23492904).3 Publications

Endogenous envelope proteins may have kept, lost or modified their original function during evolution.

Molecular Function

Anatomical structure morphogenesis, syncytium formation

Subcellular Location

Cell membrane

Expression

Expressed at higher level in placental syncytiotrophoblast. Expressed at intermediate level in testis. Seems also to be found at low level in adrenal tissue, bone marrow, breast, colon, kidney, ovary, prostate, skin, spleen, thymus, thyroid, brain and trachea. Both mRNA and protein levels are significantly increased in the brain of individuals with multiple sclerosis, particularly in astrocytes and microglia.

Structure

The cytoplasmic region is essential for the fusiogenic function.

The 17 amino acids long immunosuppressive region is present in many retroviral envelope proteins. Synthetic peptides derived from this relatively conserved sequence inhibit immune function in vitro and in vivo.

Alternative Nomenclature

Endogenous retrovirus group W member 1 antibody
env antibody
Env-W antibody
Envelope polyprotein gPr73 antibody
Enverin antibody
ERVW antibody
ERVW-1 antibody
Gp24 antibody
Gp50 antibody
HERV-7q Envelope protein antibody
HERV-W envelope protein antibody
HERVW antibody
SU antibody
Syncytin A antibody
TM antibody
Transmembrane protein antibody

General Information

Product

ERVW-1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 480-538 on human ERVW-1 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q9UQF0

Overview

This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5 (PubMed:10708449, PubMed:12050356, PubMed:23492904).3 Publications

Endogenous envelope proteins may have kept, lost or modified their original function during evolution.

Molecular Function

Anatomical structure morphogenesis, syncytium formation

Subcellular Location

Cell membrane

Expression

Expressed at higher level in placental syncytiotrophoblast. Expressed at intermediate level in testis. Seems also to be found at low level in adrenal tissue, bone marrow, breast, colon, kidney, ovary, prostate, skin, spleen, thymus, thyroid, brain and trachea. Both mRNA and protein levels are significantly increased in the brain of individuals with multiple sclerosis, particularly in astrocytes and microglia.

Structure

The cytoplasmic region is essential for the fusiogenic function.

The 17 amino acids long immunosuppressive region is present in many retroviral envelope proteins. Synthetic peptides derived from this relatively conserved sequence inhibit immune function in vitro and in vivo.

Alternative Nomenclature

Endogenous retrovirus group W member 1 antibody
env antibody
Env-W antibody
Envelope polyprotein gPr73 antibody
Enverin antibody
ERVW antibody
ERVW-1 antibody
Gp24 antibody
Gp50 antibody
HERV-7q Envelope protein antibody
HERV-W envelope protein antibody
HERVW antibody
SU antibody
Syncytin 1 antibody
TM antibody
Transmembrane protein antibody

General Information

Product

Syncytin 2 Antibody

Description

Affinity Purified Envelope glycoprotein syncytin-B Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 380-430 on human Envelope glycoprotein syncytin-B protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q8BI41

Overview

This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process (PubMed:18988732).1 Publication

Endogenous envelope proteins may have kept, lost or modified their original function during evolution but this one can still make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein mediates receptor recognition, while the transmembrane protein anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (PubMed:14694139).

Molecular Function

Syncytium formation

Subcellular Location

Virion, Cell membrane

Expression

Expressed at higher level in placenta. Expressed at lower level in adrenal, bone marrow, brain, breast, colon, kidney, lung, ovary, peripheral blood lymphocytes, prostate, skin, spleen, testis, thymus, thyroid, trachea.

Structure

Contains the CKS-17 immunosuppressive domain present in many retroviral envelope proteins. As a synthetic peptide, it inhibits immune function in vitro and in vivo.

Alternative Nomenclature

Endogenous retrovirus group FRD member 1 antibody
Envelope polyprotein antibody
ERVFRD-1 antibody
HERV FRD 6p24.1 provirus ancestral Env polyprotein antibody
HERV FRD antibody
HERV FRD provirus ancestral Env polyprotein antibody
SU antibody
Syncytin 2 antibody
Syncytin B antibody
TM antibody
Transmembrane protein antibody
UNQ6191 antibody

General Information

Product

Syncytin 2 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 80-130 on human Syncytin-2 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P60508

Overview

This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process (PubMed:18988732).1 Publication

Endogenous envelope proteins may have kept, lost or modified their original function during evolution but this one can still make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein mediates receptor recognition, while the transmembrane protein anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (PubMed:14694139).

Molecular Function

Syncytium formation

Subcellular Location

Virion, Cell membrane

Expression

Expressed at higher level in placenta. Expressed at lower level in adrenal, bone marrow, brain, breast, colon, kidney, lung, ovary, peripheral blood lymphocytes, prostate, skin, spleen, testis, thymus, thyroid, trachea.

Structure

Contains the CKS-17 immunosuppressive domain present in many retroviral envelope proteins. As a synthetic peptide, it inhibits immune function in vitro and in vivo.

Alternative Nomenclature

Endogenous retrovirus group FRD member 1 antibody
Envelope polyprotein antibody
ERVFRD-1 antibody
HERV FRD 6p24.1 provirus ancestral Env polyprotein antibody
HERV FRD antibody
HERV FRD provirus ancestral Env polyprotein antibody
SU antibody
Syncytin 2 antibody
Syncytin B antibody
TM antibody
Transmembrane protein antibody
UNQ6191 antibody

General Information

Product

NSG2 Antibody

Description

Affinity Purified Neuron-specific protein family member 2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 130-171 on human Neuron-specific protein family member 2.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:50-1:150

Immunohistochemistry

1:50-1:150

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q9Y328

Overview

Clathrin light chain binding

Molecular Function

Clathrin coat assembly, Dopamine receptor signaling pathway, Endosomal transport

Subcellular Location

Cytoplasmic vessicle membrane, Golgi apparatus, Endosome

Structure

Belongs to the NSG family.

Alternative Nomenclature

HMP19 antibody

Neuron-specific protein family member 2 antibody

Nsg2 antibody

NSG2_HUMAN antibody

Protein p19 antibody

General Information

Product

TMC2 Antibody

Description

Affinity Purified Transmembrane channel-like protein 2 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 850-906 on human Transmembrane channel-like protein 2.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:2,500-1:5,000

Protein

Uniprot #

Q8TDI7

Overview

mechanosensitive ion channel activity

voltage-gated calcium channel activity

Molecular Function

Plasma Membrane

Subcellular Location

Detected in fetal cochlea.

Expression

Belongs to the TMC family.

Structure

Transmembrane channel-like protein 2

Alternative Nomenclature

C20orf145 antibody

Transmembrane channel like protein 2 antibody

Transmembrane cochlear expressed protein 2 antibody