General Information |
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Product |
PDE1B Positive Control |
Description |
Western Blot Positive Control Phosphodiesterase 1B |
Verified Applications |
WB |
Accession # |
GenBank: EDL03912.1 |
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Quantity |
5 Applications |
Volume |
Inquire |
Concentration | The concentration of the sample is empirically set so that 20 µl per lane in Western and blotted with corresponding affinity purified antibody will give a clean band with a high signal to noise ratio on the gel. |
Form |
Western Blot Positive Control |
Storage |
-20⁰C for long term storage |
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Uniprot # |
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Overview |
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate. |
Molecular Function |
Calmodulin-binding, cAMP, cGMP, Metal-binding |
Subcellular Location |
Cytoplasm |
Structure |
Homodimer |
Alternative Nomenclature |
5''-cyclic nucleotide phosphodiesterase 1B antibody 63 kDa Cam PDE antibody Calcium/calmodulin dependent 3' 5' cyclic nucleotide Phosphodiesterase 1B antibody PDE1B1 antibody Cam PDE 1B antibody PDE1B antibody PDE1B1 antibody PDES 1B antibody Phosphodiesterase 1B antibody Phosphodiesterase 1B calmodulin dependent antibody |
Protein information supplied by UniProt
Fabgennix PDE1B Antibody has been used in 10 Publications |
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Petersen, T. S., et al. "Distribution and function of 3', 5'-Cyclic-AMP phosphodiesterases in the human ovary." Molecular and cellular endocrinology (2015). PMID25578602
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Immunohistochemistry; Human |
Yougbaré, Issaka, et al. "Cyclic GMP catabolism up-regulation in MRL/lpr lupus-prone mice is associated with organ remodeling." Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1842.7 (2014): 916-926. PMID24631654
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Immunohistochemistry, Western Blot; Mouse |
Genders, Amanda J., et al. "cGMP phosphodiesterase inhibition improves the vascular and metabolic actions of insulin in skeletal muscle." American Journal of Physiology-Endocrinology and Metabolism 301.2 (2011): E342-E350.
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Immunofluorescence, Western Blot; Rat |
Abusnina, Abdurazzag, et al. "Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis." Cellular signalling 23.1 (2011): 152-160. PMID20807569
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Western Blot; Human |
Abusnina, Abdurazzag, et al. "Anti‐prolifeRative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integRator UHRF1." Molecular nutrition & food research 55.11 (2011): 1677-1689. PMID22045655
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Western Blot; Human |
Dong, Hongli, et al. "Inhibition of PDE3, PDE4 and PDE7 potentiates glucocorticoid-induced apoptosis and overcomes glucocorticoid resistance in CEM T leukemic cells." Biochemical pharmacology 79.3 (2010): 321-329. PMID19737543
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Western Blot; Human |
Tahseldar-Roumieh, Rima et al. “PDEs1-5 Activity and Expression in Tissues of Cirrhotic Rats Reveal a Role for Aortic PDE3 in NO Desensitization.” International Journal of Experimental Pathology 90.6 (2009): 605–614. PMC2803251
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Western Blot; Rat |
Ortiz-Capisano, M. Cecilia et al. “Calcium-Dependent Phosphodiesterase 1C Inhibits Renin Release from Isolated Juxtaglomerular Cells.” American Journal of Physiology - Regulatory, Integrative and Comparative Physiology297.5 (2009): R1469–R1476. PMC2853420
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Western Blot; Mouse |
Dlaboga, Daniel, Hassan Hajjhussein, and James M. O'Donnell. "Chronic haloperidol and clozapine produce different patterns of effects on phosphodiesterase-1B,-4B, and-10A expression in Rat striatum." Neuropharmacology 54.4 (2008): 745-754. PMID18222493
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Western Blot; Rat |
Baxendale, Rhona W., and Lynn R. Fraser. "Mammalian sperm phosphodiesterases and their involvement in receptor‐mediated cell signaling important for capacitation." Molecular reproduction and development 71.4 (2005): 495-508. PMID15856425
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Immunofluorescence, Western Blot; Mouse |
Publishing research using PD1B-201AP? Please let us know, we can cite the reference in this datasheet.
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P-PD1B | |||
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PD1B-BIOTIN | |||
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