General Information |
|
Product |
PDE4C Positive Control |
Description |
Western Blot Positive Control cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
Verified Applications |
WB |
Immunogen |
Purified Protein |
Accession # |
NCBI: NP_001074.2 |
|
|
Quantity |
5 Applications |
Volume |
Inquire |
Form |
Western Blot Positive Control |
Storage |
-20⁰C for long term storage |
|
|
Western Blot |
1:500-1:2,500 |
|
|
Uniprot # |
|
Overview |
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. |
Molecular Function |
Hydrolase, 3',5'-cyclic-AMP phosphodiesterase activity, cAMP binding |
Subcellular Location |
Cell projection > cillium |
Expression |
Expressed in various tissues but not in cells of the immune system. |
Structure |
Part of a complex containing AKAP5, ADCY5, ADCY6 and PKD2. |
Alternative Nomenclature |
5''-cyclic phosphodiesterase 4C antibody cAMP specific 3' 5' cyclic phosphodiesterase 4C antibody cAMP-specific 3'' antibody DPDE 1 antibody MGC126222 antibody PDE 21 antibody PDE 4C antibody Pde4c antibody Phosphodiesterase 4C antibody Phosphodiesterase E1 dunce homolog antibody Phosphodiesterase type 4C antibody |
Protein information supplied by UniProt
FabGennix PDE4C Antibody has been used in 15 Publications
Applications: Coimmunoprecipitation, Immunocytochemistry, Immunohistochemistry, and Western blot
Reactivity: Human, Mouse, and Rat
|
|
Cheng, Hao, et al. "siRNA‑mediated silencing of phosphodiesterase 4B expression affects the production of cytokines in endotoxin‑stimulated primary cultured microglia." Experimental and Therapeutic Medicine 12.4 (2016).
|
PMID: 27698721 Applications: Western Blot Reactivity: Rat |
Ji, Qing, et al. "Intrathecal injection of phosphodiesterase 4B-specific siRNA attenuates neuropathic pain in rats with L5 spinal nerve ligation." Molecular medicine reports 13.2 (2016).
|
PMCID: 26706904 Applications: Western Blot Reactivity: Rat |
Massimi, Mara, et al. "Increase of Intracellular Cyclic AMP by PDE4 Inhibitors Affects HepG2 Cell Cycle Progression and Survival." Journal of Cellular Biochemistry (2016).
|
PMCID: 27859531 Applications: Western Blot Reactivity: Human |
Petersen, T. S., et al. "Distribution and function of 3', 5'-Cyclic-AMP phosphodiesterases in the human ovary." Molecular and cellular endocrinology (2015).
|
PMID: 25578602 Applications: Immunohistochemistry Reactivity: Human |
Yougbaré, Issaka, et al. "NCS 613 Exhibits Anti-Inflammatory Effects On Pbmcs From Lupus Patients By Inhibiting P38 MAPK And NF-Κb Signalling Pathways While Reducing Proinflammatory Cytokine Production." Canadian Journal Of Physiology & Pharmacology 91.5 (2013).
|
PMID: 23656347 Applications: Immunohistochemistry, Western Blot Reactivity: Human |
Haque, Mohammed Z., Paulo S. Caceres, and Pablo A. Ortiz. “β-Adrenergic Receptor Stimulation Increases Surface NKCC2 Expression in Rat Thick Ascending Limbs in a Process Inhibited by Phosphodiesterase 4.” American Journal of Physiology - Renal Physiology 303.9 (2012).
|
PMCID: 3518189 Applications: Western Blot Reactivity: Rat |
Keravis, Thérèse et al. “Disease Progression in MRL/lpr Lupus-Prone Mice Is Reduced by NCS 613, a Specific Cyclic Nucleotide Phosphodiesterase Type 4 (PDE4) Inhibitor.” Ed. Pierre Bobé. PLoS ONE 7.1 (2012).
|
PMCID: 3256138 Applications: Western Blot Reactivity: Mouse |
Abusnina, Abdurazzag, et al. "Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis." Cellular signalling 23.1 (2011).
|
PMID: 20807569 Applications: Western Blot Reactivity: Human |
Yougbare, Issaka, et al. "NCS 613, a potent and specific PDE4 inhibitor, displays anti-inflammatory effects on Human lung tissues." American Journal of Physiology-Lung Cellular and Molecular Physiology 301.4 (2011).
|
PMID: 21784969 Applications: Immunocytochemistry, Western Blot Reactivity: Human |
Tahseldar-Roumieh, Rima et al. “PDEs1-5 Activity and Expression in Tissues of Cirrhotic Rats Reveal a Role for Aortic PDE3 in NO Desensitization.” International Journal of Experimental Pathology 90.6 (2009).
|
PMID: 2803251 Applications: Western Blot Reactivity: Rat |
Whitaker, Christopher M., and Nigel G. F. Cooper. “The Novel Distribution of Phosphodiesterase-4 Subtypes Within the Rat Retina.” Neuroscience 163.4 (2009).
|
PMCID: 2774823 Applications: Western Blot Reactivity: Rat |
Campos-Toimil, M et al. “Short-Term or Long-Term Treatments with a Phosphodiesterase-4 (PDE4) Inhibitor Result in Opposing Agonist-Induced Ca2+ Responses in Endothelial Cells.” British Journal of Pharmacology 154.1 (2008).
|
PMCID: 2438981 Applications: Western Blot Reactivity: Human |
Sachs, Benjamin D. et al. “P75 Neurotrophin Receptor Regulates Tissue Fibrosis through Inhibition of Plasminogen Activation via a PDE4/cAMP/PKA Pathway.” The Journal of Cell Biology 177.6 (2007). |
PMCID: 2064370 Applications: Coimmunoprecipitation, Western Blot Reactivity: Mouse |
Murray, Fiona, et al. "Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: role for PDE1." American Journal of Physiology-Lung Cellular and Molecular Physiology 292.1 (2007).
|
PMID: 16980375 Applications: Western Blot Reactivity: Human |
Gallagher, Helen C., et al. "Valproate activates phosphodiesterase-mediated cAMP degradation: relevance to C6 glioma G1 phase progression." Neurotoxicology and teratology 26.1 (2004).
|
PMID: 15001216 Applications: Western Blot Reactivity: Human |
Publishing research using PD4C-301AP? Please let us know, we can cite the reference in this datasheet.
Product | Note | Status | Price | |
---|---|---|---|---|
|
PD4C-301AP | |||
|
PD4C-FITC | |||
|
P-PD4C | |||
|
PD4C-BIOTIN | |||
Display accessory details |
Select your currency:
(c) FabGennix International Inc.