General Information |
|
Product |
Eprhin Receptor A5 Antibody BIOTIN-Conjugated |
Description |
BIOTIN-Conjugated Ephrin Type-1 Receptor isoform a Antibody |
Verified Applications |
ELISA, WB |
Host |
Rabbit |
Species Cross Reactivity |
Mouse, Rat |
Immunogen |
Synthetic peptide taken within amino acid region 600-700 on human EphA R5 protein. |
Accession # |
NCBI: NP_004430 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.55-0.75 µg/µl in antibody stabilization buffer |
Form |
BIOTIN-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
DB |
1:10,000 |
ELISA |
1:10,000 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity). |
Molecular Function |
ATP-binding, Nucleotide-binding |
Subcellular Location |
Membrane; Single-pass type I membrane protein |
Expression |
Almost exclusively expressed in the nervous system in cortical neurons, cerebellar Purkinje cells and pyramidal neurons within the cortex and hippocampus. Display an increasing gradient of expression from the forebrain to hindbrain and spinal cord. |
Structure |
Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). |
Alternative Nomenclature |
Brain-specific kinase antibody bsk antibody CEK 7 antibody Eck like sequence 1 antibody EHK 1 antibody EK7 antibody Els 1 antibody Eph homology kinase 1 antibody EPH-like kinase 7 antibody EphA5 antibody Ephrin type-A receptor 5 antibody HEK 7 antibody Rek 7 antibody TYRO 4 antibody Tyrosine protein kinase receptor EHK 1 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
P-EPHAR5 | |||
|
EPHAR5-501AP | |||
|
EPHAR5-FITC | |||
|
PC-EPHAR5 | |||
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