General Information
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Product
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FOLR1 Antibody BIOTIN
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Description
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BIOTIN-Conjugated Folate receptor Alpha Antibody
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Verified Applications
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ELISA, ICC/IF, IHC, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 200-250 on mouse Folate receptor alpha protein.
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.5 µg/µl in antibody stabilization buffer
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Immunoglobulin
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IgG
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Form
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BIOTIN-Conjugated
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Purification Method
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Immobilized antigen affinity chromatography
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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ELISA
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1:50,000
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Immunofluorescence |
1:50-1:150 |
Immunohistochemistry |
1:50-1:150 |
Immunoprecipitation
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1:200
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Western Blot
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1:500
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Protein
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Uniprot #
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P35846
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Overview
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Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. Required for renal folate reabsorption.
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Molecular Function
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Receptor
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Subcellular Location
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Cell membrane, Cytoplasmic vesicle, Endosome, Membrane, Secreted
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Expression
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Detected in kidney proximal tubules.
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Structure
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Belongs to the folate receptor family.
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Alternative Nomenclature
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adult antibody
Adult folate binding protein antibody
FBP antibody
Folate Receptor 1 Adult antibody
Folate receptor 1 antibody
Folate receptor alpha antibody
Folate receptor antibody
FOLR antibody
FOLR1 antibody
FR alpha antibody
KB cells FBP antibody
MOV18 antibody
Ovarian cancer associated antigen antibody
Ovarian tumor associated antigen MOv18 antibody
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