Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor.
Molecular Function
Adenylate cyclase activity; ATP binding; Magnesium ion binding; Manganese ion binding
Subcellular Location
Cell membrane, Cytoplasm, Cytoskeleton, Membrane
Expression
Expressed in testis.
Structure
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.