General Information |
|
Product |
PDE4B Peptide |
Description |
Antigenic Blocking Peptide cAMP-specific 3',5'-cyclic phosphodiesterase 4B C-epitope |
Verified Applications |
Immunodepletion, Immunocompetition |
Peptide Description |
Synthetic peptide common to all PDE4B subtypes taken near C-terminal |
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|
Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Determinant |
C-epitope |
Storage |
-20⁰C for long term storage |
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|
Competition/Depletion assay |
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Uniprot # |
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Overview |
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory |
Molecular Function |
Hydrolase, 3',5'-cyclic-AMP phosphodiesterase activity, cAMP binding |
Expression |
Expressed in brain, heart, lung and skeletal muscle. |
Alternative Nomenclature |
5''-cyclic phosphodiesterase 4B antibody cAMP-specific 3'' antibody cAMP-specific 3',5'-cyclic phosphodiesterase 4B antibody DPDE4 antibody dunce-like phosphodiesterase E4 antibody MGC126529 antibody PDE 4B antibody PDE IVB antibody PDE32 antibody PDE4B5 antibody PDEIVB antibody Phosphodiesterase 4B antibody Phosphodiesterase-4B cAMP-specific (dunce (Drosophila)-homolog) antibody |
Protein information supplied by UniProt
Fabgennix PDE4B Antibody has been used in 42 Publications |
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Kedia, George T., et al. "Expression and Distribution of Phosphodiesterase Isoenzymes in the Human Male Urethra." Urology (2015). PMID25704994 |
Immunofluorescence, Western Blot; Human |
Petersen, T. S., et al. "Distribution and function of 3', 5'-Cyclic-AMP phosphodiesterases in the human ovary." Molecular and cellular endocrinology (2015). PMID25578602 |
Immunohistochemistry; Human |
Guo, Jiejie, et al. "Etazolate abrogates the lipopolysaccharide (LPS)-induced downregulation of the cAMP/pCREB/BDNF signaling, neuroinflammatory response and depressive-like behavior in mice." Neuroscience 263 (2014): 1-14. PMID24434771 |
Western Blot; Mouse |
Zhai, Kui, et al. "Phosphodiesterase types 3 and 4 regulate the phasic contraction of neonatal rat bladder smooth myocytes via distinct mechanisms." Cellular signalling 26.5 (2014): 1001-1010.PMID24463006 |
Western Blot; Human |
Hiramoto, Kenichi, et al. "Role of phosphodiesterase 2 in growth and invasion of human malignant melanoma cells." Cellular signalling 26.9 (2014): 1807-1817. PMID24705027 |
Western Blot; Rat |
Wang, Zhen-Zhen et al. “RNA Interference-Mediated Phosphodiesterase 4D Splice Variants Knock-down in the Prefrontal Cortex Produces Antidepressant-Like and Cognition-Enhancing Effects.” British Journal of Pharmacology 168.4 (2013): 1001–1014. PMID23003922 |
Western Blot; Mouse |
Sanabra, Cristina, Emily M. Johansson, and Guadalupe Mengod. "Critical role for PDE4 subfamilies in the development of experimental autoimmune encephalomyelitis." Journal of chemical neuroanatomy 47 (2013): 96-105. PMID23274837 |
Immunohistochemistry; Mouse |
Yougbaré, Issaka, et al. "NCS 613 Exhibits Anti-Inflammatory Effects On Pbmcs From Lupus Patients By Inhibiting P38 MAPK And NF-Κb Signalling Pathways While Reducing Proinflammatory Cytokine Production." Canadian Journal Of Physiology & Pharmacology 91.5 (2013): 353-361. PMID23656347 |
Immunocytochemistry, Western Blot; Human |
Haque, Mohammed Z., Paulo S. Caceres, and Pablo A. Ortiz. “β-Adrenergic Receptor Stimulation Increases Surface NKCC2 Expression in Rat Thick Ascending Limbs in a Process Inhibited by Phosphodiesterase 4.” American Journal of Physiology - Renal Physiology 303.9 (2012): F1307–F1314. PMC3518189 |
Western Blot; Rat |
Johansson, Emily M., Cristina Sanabra, and Guadalupe Mengod. "Sex‐related differences of cAMP‐specific PDE4B3 mRNA in oligodendrocytes following systemic inflammation." Glia 60.12 (2012): 1815-1825. PMID22848007 |
Western Blot; Mouse |
For a complete listing of FabGennix PDE4B publications, please click here.
Publishing research using PD4B-201AP? Please let us know, we can cite the reference in this datasheet.
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PD4B.212-BIOTIN | |||
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PC-PD4B | |||
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