General Information |
|
Product |
PARD6B Antibody FITC |
Description |
FITC-Conjugated Partitioning Defective 6 homolog beta Antibody |
Verified Applications |
ELISA, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic peptide corresponding to amino acids within region 300-350 on human Partitioning Defective 6 homolog beta. |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.5-1.5 µg/µl in antibody stabilization buffer |
Immunoglobulin |
IgG |
Form |
FITC-Conjugated |
Purification Method |
Immobilized antigen affinity chromatography |
Clonality |
Polyclonal |
Storage |
-20?C for long term storage |
|
|
ELISA |
1:50,000 |
Immunoprecipitation |
1:200 |
Western Blot |
1:500-1:5,000 |
|
|
Uniprot # |
|
Overview |
Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. |
Molecular Function |
protein kinase C binding Rho GTPase binding |
Subcellular Location |
Cell membrane, Cytoplasm |
Expression |
Expressed in pancreas and in both adult and fetal kidney. Weakly expressed in placenta and lung. Not expressed in other tissues. |
Structure |
The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases. The PDZ domain mediates interaction with MPP5. |
Alternative Nomenclature |
OTTHUMP00000031269 antibody PAR 6 beta antibody Par 6 partitioning defective 6 homolog beta (C. elegans) antibody PAR6B antibody PARD6 beta antibody PARD6B antibody partitioning defective 6 homolog beta antibody partitioning-defective protein 6, C. elegans, homolog of, beta antibody |
Protein information supplied by UniProt.
Product | Note | Status | Price | |
---|---|---|---|---|
|
PARD6B-101AP | |||
|
PARD6B-BIOTIN | |||
|
P-PARD6B | |||
|
PC-PARD6B | |||
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