General Information

Product

CD10 Antibody

Description

Affinity Purified Neprilysin Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Recombinant CD10 protein.

Accession #

NCBI: NP_009218

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Uniprot #

P08473

Overview

Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. angiotensin maturation; cellular response to UV; replicative senescence.

Molecular Function

Hydrolase, Metalloprotease, Protease

Subcellular Location

Cell membrane, Membrane

Expression

Adipose tissue; duodenum; kidney; small intestine

Structure

Belongs to the peptidase M13 family

Alternative Nomenclature

Atriopeptidase antibody

CALLA antibody

CD10 antibody

Common acute lymphocytic leukemia antigen antibody

DKFZp686O16152 antibody

EC 3.4.24.11 antibody

Enkephalinase antibody

EPN antibody

gp100 antibody

Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10) antibody

Membrane metallo endopeptidase antibody

MGC126681 antibody

MGC126707 antibody

MME antibody

NEP antibody

Neprilysin antibody

Neutral endopeptidase antibody

SFE antibody

Skin fibroblast elastase antibody

General Information

Product

FXIIIA Antibody

Description

Affinity Purified Blood coagulation factor XIII a subunit Antibody C-epitope

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Cat, Human, Monkey, Mouse

Immunogen

Synthetic peptide taken within amino acid region 700-732 on human factor XIII A subunit protein.

Accession #

GenBank: AAA52415.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P00488

Overview

Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.

Molecular Function

Metal ion binding; Protein-glutamine gamma-glutamyltransferase activity

Subcellular Location

Cytoplasm. Secreted

Structure

Tetramer of two A chains and two B chains.

Alternative Nomenclature

bA525O21.1 (coagulation factor XIII, A1 polypeptide) antibody

Coagulation factor XIII A chain antibody

F13A antibody

F13A1 antibody

Fibrin stabilizing factor, A subunit antibody

Fibrinoligase antibody

FSF, A subunit antibody

FXIIIA antibody

Protein-glutamine gamma-glutamyltransferase A chain antibody

TGase antibody

Transglutaminase A chain antibody

General Information

Product

FXIIIA Antibody

Description

Affinity Purified Blood coagulation factor XIII a subunit Antibody N-epitope

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Cat, Human, Monkey, Mouse

Immunogen

Synthetic peptide taken within amino acid region 1-50 on human factor XIII A subunit protein.

Accession #

GenBank: AAA52415.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P00488

Overview

Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.

Molecular Function

Metal ion binding; Protein-glutamine gamma-glutamyltransferase activity

Subcellular Location

Cytoplasm. Secreted

Structure

Tetramer of two A chains and two B chains.

Alternative Nomenclature

bA525O21.1 (coagulation factor XIII, A1 polypeptide) antibody

Coagulation factor XIII A chain antibody

F13A antibody

F13A1 antibody

Fibrin stabilizing factor, A subunit antibody

Fibrinoligase antibody

FSF, A subunit antibody

FXIIIA antibody

Protein-glutamine gamma-glutamyltransferase A chain antibody

TGase antibody

Transglutaminase A chain antibody

General Information

Product

CD10 Antibody

Description

Affinity Purified Neprilysin Antibody N-epitope

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 200-250 on human Neprilysin protein.

Accession #

NCBI: NP_009218

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.72-0.78 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Uniprot #

P08473

Overview

Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. angiotensin maturation; cellular response to UV; replicative senescence

Molecular Function

Hydrolase, Metalloprotease, Protease

Subcellular Location

Cell membrane, Membrane

Expression

Adipose tissue; duodenum; kidney; small intestine

Structure

Belongs to the peptidase M13 family

Alternative Nomenclature

Atriopeptidase antibody

CALLA antibody

CD10 antibody

Common acute lymphocytic leukemia antigen antibody

DKFZp686O16152 antibody

EC 3.4.24.11 antibody

Enkephalinase antibody

EPN antibody

gp100 antibody

Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10) antibody

Membrane metallo endopeptidase antibody

MGC126681 antibody

MGC126707 antibody

MME antibody

NEP antibody

Neprilysin antibody

Neutral endopeptidase antibody

SFE antibody

Skin fibroblast elastase antibody

General Information

Product

CD10 Antibody

Description

Affinity Purified Neprilysin Antibody Mid Region

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 360-410 on human Neprilysin protein.

Accession #

NCBI: NP_009218

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.72-0.78 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

Mid Region

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Uniprot #

P08473

Overview

Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. angiotensin maturation; cellular response to UV; replicative senescence

Molecular Function

Hydrolase, Metalloprotease, Protease

Subcellular Location

Cell membrane, Membrane

Expression

Adipose tissue; duodenum; kidney; small intestine

Structure

Belongs to the peptidase M13 family

Alternative Nomenclature

Atriopeptidase antibody

CALLA antibody

CD10 antibody

Common acute lymphocytic leukemia antigen antibody

DKFZp686O16152 antibody

EC 3.4.24.11 antibody

Enkephalinase antibody

EPN antibody

gp100 antibody

Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10) antibody

Membrane metallo endopeptidase antibody

MGC126681 antibody

MGC126707 antibody

MME antibody

NEP antibody

Neprilysin antibody

Neutral endopeptidase antibody

SFE antibody

Skin fibroblast elastase antibody

General Information

Product

CD10 Antibody

Description

Affinity Purified Neprilysin Antibody C-epitope

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 450-500 on human Neprilysin protein.

Accession #

NCBI: NP_009218

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.72-0.78 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Uniprot #

P08473

Overview

Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. angiotensin maturation; cellular response to UV; replicative senescence

Molecular Function

Hydrolase, Metalloprotease, Protease

Subcellular Location

Cell membrane, Membrane

Expression

Adipose tissue; duodenum; kidney; small intestine

Structure

Belongs to the peptidase M13 family

Alternative Nomenclature

Atriopeptidase antibody

CALLA antibody

CD10 antibody

Common acute lymphocytic leukemia antigen antibody

DKFZp686O16152 antibody

EC 3.4.24.11 antibody

Enkephalinase antibody

EPN antibody

gp100 antibody

Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10) antibody

Membrane metallo endopeptidase antibody

MGC126681 antibody

MGC126707 antibody

MME antibody

NEP antibody

Neprilysin antibody

Neutral endopeptidase antibody

SFE antibody

Skin fibroblast elastase antibody

General Information

Product

CD10 Antibody

Description

Affinity Purified Neprilysin Antibody Extreme C-epitope

Verified Applications

CM, ELISA, ICC/IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 700-750 on human Neprilysin protein.

Accession #

NCBI: NP_009218

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.72-0.78 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

Extreme C-epitope

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Uniprot #

P08473

Overview

Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. angiotensin maturation; cellular response to UV; replicative senescence

Molecular Function

Hydrolase, Metalloprotease, Protease

Subcellular Location

Cell membrane, Membrane

Expression

Adipose tissue; duodenum; kidney; small intestine

Structure

Belongs to the peptidase M13 family

Alternative Nomenclature

Atriopeptidase antibody

CALLA antibody

CD10 antibody

Common acute lymphocytic leukemia antigen antibody

DKFZp686O16152 antibody

EC 3.4.24.11 antibody

Enkephalinase antibody

EPN antibody

gp100 antibody

Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10) antibody

Membrane metallo endopeptidase antibody

MGC126681 antibody

MGC126707 antibody

MME antibody

NEP antibody

Neprilysin antibody

Neutral endopeptidase antibody

SFE antibody

Skin fibroblast elastase antibody

General Information

Product

CD10 Antibody

Description

Affinity Purified Neprilysin Antibody Extreme N-epitope

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 100-150 on human Neprilysin protein.

Accession #

NCBI: NP_009218

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.72-0.78 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

Extreme N-epitope

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Uniprot #

P08473

Overview

Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. angiotensin maturation; cellular response to UV; replicative senescence

Molecular Function

Hydrolase, Metalloprotease, Protease

Subcellular Location

Cell membrane, Membrane

Expression

Adipose tissue; duodenum; kidney; small intestine

Structure

Belongs to the peptidase M13 family

Alternative Nomenclature

Atriopeptidase antibody

CALLA antibody

CD10 antibody

Common acute lymphocytic leukemia antigen antibody

DKFZp686O16152 antibody

EC 3.4.24.11 antibody

Enkephalinase antibody

EPN antibody

gp100 antibody

Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10) antibody

Membrane metallo endopeptidase antibody

MGC126681 antibody

MGC126707 antibody

MME antibody

NEP antibody

Neprilysin antibody

Neutral endopeptidase antibody

SFE antibody

Skin fibroblast elastase antibody

General Information

Product

Presenilin 1 Antibody

Description

Affinity Purified Presenilin 1 (Alzheimer disease 3) Antibody C-epitope

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Cat, Human, Monkey, Pig, Rat

Immunogen

Synthetic peptide taken within amino acid region 417-467 on human Presnelin-1 protein.

Accession #

GenBank:  EAW81096.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

1.00-1.25 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P49768

Overview

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.

Molecular Function

Hydrolase, Protease

Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell surface

Expression

Expressed in a wide range of tissues including various regions of the brain, liver, spleen and lymph nodes.

Structure

Homodimer

Alternative Nomenclature

AD3 antibody

FAD antibody

Homo Sapiens Clone CC44 Senilin 1 antibody

Presenilin-1 CTF12 antibody

Protein S182 antibody

PS 1 antibody

PSEN1 antibody

S182 antibody

General Information

Product

Presenilin 1 Antibody Affinity Purified

Description

Affinity Purified Presenilin 1 (Alzheimer disease 3) Antibody N-epitope

Verified Applications

ELISA, IMM, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Cat, Human, Monkey, Pig

Immunogen

Synthetic peptide taken within amino acid region 1-50 on Presenilin 1 (Alzheimer disease 3) protein.

Accession #

GenBank:  EAW81096.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

1.00-1.25 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P49768

Overview

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.

Molecular Function

Hydrolase, Protease

Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell surface

Expression

Expressed in a wide range of tissues including various regions of the brain, liver, spleen and lymph nodes.

Structure

Homodimer

Alternative Nomenclature

AD3 antibody

FAD antibody

Homo Sapiens Clone CC44 Senilin 1 antibody

Presenilin-1 CTF12 antibody

Protein S182 antibody

PS 1 antibody

PSEN1 antibody

S182 antibody