General Information
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Product
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THAP1 Peptide
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Description
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Antigenic Blocking Peptide THAP domain-containing protein 1 Antibody
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Verified Applications
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Immunodepletion, Immunocompetition
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Species Cross Reactivity
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Human; Predicted: Mouse, Rat
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Peptide Description
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Synthetic peptide taken within amino acid region 150-210 on human THAP domain-containing protein 1.
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Accession #
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GenBank: CAG33537
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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Q9NVV9
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Overview
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DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.
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Molecular Function
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Identical protein binding, Sequence-specific DNA binding, Zinc ion binding
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Subcellular Location
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Nucleus > nucleoplasm, PML body
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Expression
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Highly expressed in heart, skeletal muscle, kidney and liver. Weaker expression in brain and placenta.
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Structure
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Belongs to the THAP1 family.
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Alternative Nomenclature
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Nuclear proapoptotic factor antibody
THAP 1 antibody
THAP domain containing apoptosis associated protein 1 antibody
THAP domain containing protein 1 antibody
THAP domain protein 1 antibody
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