DNMT3b Antibody
Catalog no. DNMT3B-101AP · Research Use Only
$285 per 100 µg. Ships within 2–3 business days from the U.S.
DNMT3B-101AP — affinity purified Rabbit antibody against Dnmt3b. Validated for ELISA, IP, WB. Reacts with Human, Mouse, Rat.
Specifications
| Catalog number | DNMT3B-101AP |
|---|---|
| Target | Dnmt3b |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IP, WB |
| Conjugate | Unconjugated |
| Purity | Affinity Purified |
| Immunogen | Synthetic peptide corresponding to amino acids within region 50-100 on mouse DNA (cytosine-5)-methyltransferase 3B protein. |
| Size | 100 µg |
| Storage | -20°C |
| UniProt | O88509 |
About this target
DNMT3b Antibody (DNMT3B-101AP) is an affinity-purified rabbit polyclonal antibody against Dnmt3b. It is listed for ELISA, IP, WB and reacts with Human, Mouse, Rat. For research use only. Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Subcellular location: Nucleus. Note=Accumulates in the major satellite repeats at pericentric heterochromatin.
Documents
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FabGennix International, Inc., 9191 Kyser Way, Frisco, TX 75033. For research use only. Not for diagnostic or therapeutic use.