HYPE Blocking Peptide
Catalog no. P-HYPE · Research Use Only
$155 per 250 µg. Ships within 2–3 business days from the U.S.
P-HYPE — affinity-purified Rabbit antibody against HYPE. Validated for Immunodepletion, Immunocompetition.
Specifications
| Catalog number | P-HYPE |
|---|---|
| Target | HYPE |
| Applications | Immunodepletion, Immunocompetition |
| Conjugate | Unconjugated |
| Immunogen | Synthetic peptide corresponding to amino acids within region 400-450 on mouse Protein adenylyltransferase FICD. |
| Size | 250 µg |
| Storage | -20°C |
| UniProt | Q9BVA6 |
About this target
HYPE Blocking Peptide is the antigenic blocking peptide for the HYPE antibody HYPE-101AP. Pre-incubating the antibody with the peptide competes away specific binding, which helps confirm that a signal comes from the intended target. Supplied at 250 µg, for research use only. Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context. The side chain of Glu-231 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place. Acts as a key regulator of the ERN1/IRE1-mediated unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of HSPA5/BiP. In unstressed cells, acts as an adenylyltransferase by mediating AMPylation of HSPA5/BiP at 'Thr-518', thereby inactivating it. Subcellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Documents
Related products
- HYPE Antibody (HYPE-101AP)
- HYPE Antibody BIOTIN (HYPE-BIOTIN)
- HYPE Antibody FITC (HYPE-FITC)
- HYPE Positive Control (PC-HYPE)
FabGennix International, Inc., 9191 Kyser Way, Frisco, TX 75033. For research use only. Not for diagnostic or therapeutic use.