Klotho Blocking Peptide
Catalog no. P-KLOTHO · Research Use Only
$155 per 250 µg. Ships within 2–3 business days from the U.S.
P-KLOTHO — affinity-purified Rabbit antibody against Klotho. Validated for Immunodepletion, Immunocompetition.
Specifications
| Catalog number | P-KLOTHO |
|---|---|
| Target | Klotho |
| Applications | Immunodepletion, Immunocompetition |
| Conjugate | Unconjugated |
| Immunogen | Synthetic peptide corresponding to amino acids within region 300-350 on human Klotho protein. |
| Size | 250 µg |
| Storage | -20°C |
| UniProt | Q9UEF7 |
About this target
Klotho Blocking Peptide is the antigenic blocking peptide for the Klotho antibody KLOTHO-101AP. Pre-incubating the antibody with the peptide competes away specific binding, which helps confirm that a signal comes from the intended target. Supplied at 250 µg, for research use only. Exhibits beta-glucuronidase activity in vitro despite lacking canonical catalytic Glu residues of glycosyl hydrolase 1 family enzymes. Hydrolyzes steroid beta-D-glucuronides including estradiol-3-beta-D-glucuronide, estrone-3-beta-D-glucuronide and estriol-3-beta-D-glucuronide. Essential for the interaction between FGF23 and FGFR1 and for FGF23-mediated regulation of renal vitamin D and phosphate homeostasis.; FUNCTION: The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling. Subcellular location: [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Apical cell membrane; Single-pass type I membrane protein.
Documents
Related products
- Klotho Antibody (KLOTHO-101AP)
- Klotho Antibody BIOTIN (KLOTHO-BIOTIN)
- Klotho Antibody FITC (KLOTHO-FITC)
- Klotho Positive Control (PC-KLOTHO)
FabGennix International, Inc., 9191 Kyser Way, Frisco, TX 75033. For research use only. Not for diagnostic or therapeutic use.