Phospho-PLK4 Antibody
Catalog no. PPLK4-140AP · Research Use Only
$375 per 100 µg. Ships within 2–3 business days from the U.S.
PPLK4-140AP — affinity purified Rabbit antibody against Phospho-PLK4. Validated for ELISA, IP, WB. Reacts with Human.
Specifications
| Catalog number | PPLK4-140AP |
|---|---|
| Target | Phospho-PLK4 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Reactivity | Human |
| Applications | ELISA, IP, WB |
| Conjugate | Unconjugated |
| Purity | Affinity Purified |
| Immunogen | Phosphorylated synthetic peptide corresponding to amino acids within region 300-350 on human PLK4 protein. |
| Size | 100 µg |
| Storage | -20°C |
| UniProt | O00444 |
About this target
Phospho-PLK4 Antibody (PPLK4-140AP) is an affinity-purified rabbit polyclonal antibody against Phospho-PLK4. It is listed for ELISA, IP, WB and reacts with Human. For research use only. Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus, nucleolus. Cleavage furrow. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Documents
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FabGennix International, Inc., 9191 Kyser Way, Frisco, TX 75033. For research use only. Not for diagnostic or therapeutic use.