YAP1 Positive Control
Catalog no. PC-YAP1 · Research Use Only
$200 per 5 applications. Ships within 2–3 business days from the U.S.
PC-YAP1 — affinity-purified Rabbit antibody against YAP1. Validated for WB.
Specifications
| Catalog number | PC-YAP1 |
|---|---|
| Target | YAP1 |
| Applications | WB |
| Conjugate | Unconjugated |
| Immunogen | Partially purified human YAP1 protein. |
| Size | 5 applications |
| Storage | -20°C |
| UniProt | P46937 |
About this target
YAP1 Positive Control is a Western blot positive control for YAP1 antibodies. It gives a reference band to confirm the antibody and the blotting procedure are working. Supplied for 5 applications, for research use only. Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ. Subcellular location: Cytoplasm. Nucleus. Cell junction, tight junction. Cell membrane. Note=Both phosphorylation and cell density can regulate its subcellular localization. Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus.
Documents
Related products
- YAP1 Blocking Peptide (P-YAP1)
- YAP1 Antibody (YAP1-101AP)
- YAP1 Antibody BIOTIN (YAP1-BIOTIN)
- YAP1 Antibody FITC (YAP1-FITC)
FabGennix International, Inc., 9191 Kyser Way, Frisco, TX 75033. For research use only. Not for diagnostic or therapeutic use.