General Information |
|
Product |
IRE1 Antibody FITC |
Description |
FITC-Conjugated Serine/Threonine-protein kinase/endoribonuclease IRE1 Antibody |
Verified Applications |
ELISA, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic peptide corresponding to unique amino acid sequence within amino acid region 900-977 on human IRE1A protein. |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.59-0.68 µg/µl in antibody stabilization buffer |
Immunoglobulin |
IgG |
Form |
FITC-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
DB |
1:10,000 |
ELISA |
1:10,000 |
Immunoprecipitation |
1:200 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis. |
Molecular Function |
Hydrolase, Kinase, Serine/threonine-protein kinase, Transferase |
Subcellular Location |
Endoplasmic reticulum membrane; Single-pass type 1 membrane protein |
Expression |
Ubiquitously expressed. High levels observed in pancreatic tissue. |
Structure |
Interacts with DAB2IP (via PH domain); the interaction occurs in a ER stress-induced dependent manner and is required for subsequent recruitment of TRAF2 to ERN1 (By similarity). Homodimer; disulfide-linked. Dimer formation is driven by hydrophobic intera |
Alternative Nomenclature |
Endoplasmic reticulum (ER) to nucleus signalling 1 antibody Endoribonuclease antibody ERN 1 antibody hIRE 1p antibody IRE1P antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
IRE1A-101AP | |||
|
P-IRE1A | |||
|
IRE1A-BIOTIN | |||
|
PC-IRE1A | |||
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