General Information |
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Product |
PDE4A4 Positive Control |
Description |
Western Blot Positive Control cAMP specific phosphodiesterase 4A variant pde46 |
Verified Applications |
WB |
Immunogen |
Purified Protein |
Accession # |
GenBank: EAW74861.1 |
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Quantity |
5 Applications |
Volume |
Inquire |
Form |
Western Blot Positive Control |
Storage |
-20⁰C for long term storage |
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Western Blot |
1:500 |
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Uniprot # |
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Overview |
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. |
Molecular Function |
Hydrolase, 3',5'-cyclic-AMP phosphodiesterase activity, cAMP binding |
Subcellular Location |
Isoform 1: Cytoplasm › perinuclear region, Isoform 2: Cytoplasm, Cell projection, Isoform 4: Membrane; Peripheral membrane protein Isoform 6 : Cytoplasm › perinuclear region Isoform 7 : Cytoplasm. Membrane |
Expression |
Isoform 1 is widely expressed. Isoform 2 is abundant in liver, stomach, testis, thyroid and adrenal glands. It is also found in placenta, kidney, pancreas, ovary, uterus, skin, monocytes, mast cells, macrophages, as well as in bronchial smooth muscle. Isoform 6 is expressed at high levels in the heart and small intestine. It is also found in the brain, kidney, spleen, colon, salivary gland, ovary and peripheral blood lymphocytes. Isoform 7 is expressed predominantly in skeletal muscle and brain and at lower levels in the testis. Isoform 7 is expressed in the brain. Found in specific neuronal subpopulations in cortex, spinal cord and cerebellum (at protein level). |
Structure |
Isoform 1 interacts with LYN. Isoform 2 and isoform 6 interact weakly with LYN. Isoform 1, isoform 2 and isoform 6 interact with ARRB2. |
Alternative Nomenclature |
DPDE2 antibody PDE4A antibody Phosphodiesterase 4 antibody Phosphodiesterase 4A antibody Phosphodiesterse Type 4A4 antibody |
Protein information supplied by UniProt
Fabgennix PDE4A4 Antibody has been used in 1 Publication |
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Valente, Eliane GA, et al. "L-arginine and phosphodiesterase (PDE) inhibitors counteract fibrosis in the Peyronie’s fibrotic plaque and related fibroblast cultures." Nitric Oxide 9.4 (2003): 229-244. PMID14996430
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Immunohistochemistry; Human, Rat |
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Publishing research using PD4A4-131AP? Please let us know, we can cite the reference in this datasheet.
Product | Note | Status | Price | |
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PD4A4-131AP | |||
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PD4A4-FITC | |||
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P-PD4A4 | |||
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PD4A4-BIOTIN | |||
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