General Information |
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Product |
PDE4A5 Positive Control |
Description |
Western Blot Positive Control cAMP specific phosphodiesterase 4A variant pde46 |
Verified Applications |
WB |
Immunogen |
Purified Protein |
Accession # |
GenBank: EAW74861.1 |
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Quantity |
5 Applications |
Volume |
Inquire |
Form |
Western Blot Positive Control |
Storage |
-20⁰C for long term storage |
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Western Blot |
1:750-1:1,000 |
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Uniprot # |
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Overview |
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. |
Molecular Function |
Hydrolase, 3',5'-cyclic-AMP phosphodiesterase activity, cAMP binding |
Subcellular Location |
Isoform 1: Cytoplasm › perinuclear region, Isoform 2: Cytoplasm, Cell projection, Isoform 4: Membrane; Peripheral membrane protein Isoform 6 : Cytoplasm › perinuclear region Isoform 7 : Cytoplasm. Membrane |
Expression |
Isoform 1 is widely expressed. Isoform 2 is abundant in liver, stomach, testis, thyroid and adrenal glands. It is also found in placenta, kidney, pancreas, ovary, uterus, skin, monocytes, mast cells, macrophages, as well as in bronchial smooth muscle. Isoform 6 is expressed at high levels in teh heart and small intestine. It is also found in the brain, kidney, spleen, colon, salivary gland, ovary and periphereal blood lymphocytes. Isoform 7 is expressed predominantly in skeletal muscle and brain and at lower levels in the testis. Isoform 7 is expressed in the brain. Found in specific neuronal subpopulations in cortex, spinal cord and cerebellum (at protein level). |
Structure |
Isoform 1 interacts with LYN. Isoform 2 and isoform 6 interact weakly with LYN. Isoform 1, isoform 2 and isoform 6 interact with ARRB2. |
Alternative Nomenclature |
5''-cyclic phosphodiesterase 4A antibody cAMP specific 3 5 cyclic phosphodiesterase 4A antibody cAMP-specific 3'' antibody DPDE2 antibody dunce antibody PDE46 antibody PDE4A antibody Phosphodiesterase 4 antibody phosphodiesterase 4A cAMP specific antibody phosphodiesterase E2 dunce homolog antibody |
Protein information supplied by UniProt
Fabgennix PDE4A5 Antibody has been used in 2 Publications |
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Sassi, Yassine et al. “Regulation of cAMP Homeostasis by the Efflux Protein MRP4 in Cardiac Myocytes.” The FASEB Journal 26.3 (2012): 1009–1017. PMC3289499
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Western Blot; Mouse |
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Hajjhussein, Hassan et al. “Changes in NMDA Receptor-Induced Cyclic Nucleotide Synthesis Regulate the Age-Dependent Increase in PDE4A Expression in Primary Cortical Cultures.” Brain research 1149 (2007): 58–68. PMC2720317
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Immunoprecipitation, Western Blot; Rat |
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Publishing research using PD4A5-151AP? Please let us know, we can cite the reference in this datasheet.
Product | Note | Status | Price | |
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PD4A5-151AP | |||
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PD4A5-FITC | |||
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P-PD4A5 | |||
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PD4A5-BIOTIN | |||
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