General Information |
|
Product |
PDE4A8 Antibody BIOTIN-Conjugated |
Description |
BIOTIN-Conjugated cAMP-specific 3',5'-cyclic phosphodiesterase 4A Antibody |
Verified Applications |
CM, ELISA, ICC, IF, IHC, IMM, WB |
Host |
Rabbit |
Species Cross Reactivity |
Mouse, Rat |
Immunogen |
Synthetic peptide specific only for PDE4A8 protein. |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
1.00-1.25 µg/µl in antibody stabilization buffer |
Form |
BIOTIN-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
Confocal Microscopy |
1:200 |
DB |
1:10,000 |
ELISA |
1:10,000 |
Immunocytochemistry |
1:200 |
Immunofluorescence |
1:200 |
Immunohistochemistry |
1:200 |
Immunoprecipitation |
1:250 |
Western Blot |
1:1,000 |
|
|
Uniprot # |
|
Overview |
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. |
Molecular Function |
metal ion binding, 3',5'-cyclic-AMP phosphodiesterase activity, cAMP binding |
Subcellular Location |
Isoform 1: Cytoplasm, perinuclear region; Isoform 2: Cytoplasm, perinuclear region. Cell projection, ruffle membrane; Isoform 4: Peripheral membrane protein; Isoform 6: Cytoplasm; perinuclear region; Isoform 7: Cytoplasm, Membrane |
Expression |
Isoform 1 is widely expressed. Isoform 2 is abundant in liver, stomach, testis, thyroid and adrenal glands. It is also found in placenta, kidney, pancreas, ovary, uterus, skin, monocytes, mast cells, macrophages, as well as in bronchial smooth muscle. Iso |
Structure |
Isoform 1 interacts with LYN. Isoform 2 and isoform 6 interact weakly with LYN. Isoform 1, isoform 2 and isoform 6 interact with ARRB2. |
Alternative Nomenclature |
5''-cyclic phosphodiesterase 4A antibody cAMP specific 3 5 cyclic phosphodiesterase 4A antibody cAMP-specific 3'' antibody DPDE2 antibody dunce antibody PDE46 antibody PDE4A antibody Phosphodiesterase 4 antibody phosphodiesterase 4A cAMP specific antibody phosphodiesterase E2 dunce homolog antibody |
Protein information supplied by UniProt
Fabgennix PDE4A8 Antibody has been used in 1 Publication |
|
Farooqui, Shakeel M., et al. "Surgically induced cryptorchidism-related degenerative changes in spermatogonia are associated with loss of cyclic adenosine monophosphate-dependent phosphodiesterases type 4 in abdominal testes of rats." Biology of reproduction 64.6 (2001): 1583-1589.
|
Confocal Microscopy, Immunocytochemistry, Western Blot; Rat |
Publishing research using PD4A8-121AP? Please let us know, we can cite the reference in this datasheet.
Product | Note | Status | Price | |
---|---|---|---|---|
|
P-PD4A8 | |||
|
PD4A8-121AP | |||
|
PD4A8-FITC | |||
|
PC-PD4A8 | |||
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