PDE4D7 Blocking Peptide

General Information

Product

PDE4D7 Peptide

Description

Antigenic Blocking Peptide cAMP-specific phosphodiesterase PDE4D7

Verified Applications

Immunodepletion, Immunocompetition

Peptide Description

Synthetic peptide corresponding to unique amino acid sequence on PDE4D7 variant.

Accession #

GenBank: AF536978.1

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Storage

-20⁰C for long term storage

Application Protocol

Competition/Depletion assay

Refer to competition assay protocol

Protein

Uniprot #

Q01063

Overview

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.

Molecular Function

Hydrolase, 3',5'-cyclic-nucleotide phosphodiesterase activity, ATPase binding

Subcellular Location

Cytoplasm. Membrane. Cytoplasm › cytoskeleton. Cytoplasm › cytoskeleton › microtubule organizing center › centrosome. Apical cell membrane

Expression

Expressed in brain (at protein level). Isoform 7 is detected in heart, brain, lung, kidney and testis.

Structure

Homodimer for the long isoforms. Isoforms with truncated N-termini are monomeric. Binds ARRB2. Interacts with PDE4DIP (By similarity). Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1). Interacts (via N-terminal region) with SHANK2 (via proline-rich region); the interaction is increased in a PKA-dependent manner.

Alternative Nomenclature

DPDE3 antibody

HSPDE4D antibody

PDE43 antibody

PDE4D antibody

Phosphodiesterase 4D antibody

Phosphodiesterase 4D cAMP-specific antibody