General Information |
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Product |
Phospho MAPK14 Antibody Western Blot Positive Control |
Description |
Western Blot Positive Control Phospho p38 Mitogen Activated Protein Kinase 14 Antibody |
Verified Applications |
WB |
Immunogen |
Purified Protein |
Accession # |
NCBI: NP_001306 |
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Quantity |
5 Applications |
Volume |
Inquire |
Form |
Western Blot Positive Control |
Storage |
-20⁰C for long term storage |
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Western Blot |
1:500-1:1,000 |
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Uniprot # |
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Overview |
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. MAPK14 interacts also with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. The p38 MAPKs may also have kinase-independent roles, which are thought to be due to the binding to targets in the absence of phosphorylation. |
Molecular Function |
ATP binding; MAP kinase activity; MAP kinase kinase activity; NFAT protein binding; Protein serine/threonine kinase activity |
Subcellular Location |
Cytoplasm; Nucleus |
Expression |
Brain, heart, placenta, pancreas and skeletal muscle. Expressed to a lesser extent in lung, liver and kidney. |
Structure |
Binds to a kinase interaction motif within the protein tyrosine phosphatase, PTPRR (By similarity). This interaction retains MAPK14 in the cytoplasm and prevents nuclear accumulation (By similarity). Interacts with SPAG9 and GADD45A (By similarity). Interacts with CDC25B, CDC25C, DUSP1, DUSP10, DUSP16, NP60, SUPT20H and TAB1. Interacts with casein kinase II subunits CSNK2A1 and CSNK2B. |
Alternative Nomenclature |
CSAID-binding protein antibody CSBP antibody CSBP1 antibody CSBP2 antibody Cytokine suppressive anti-inflammatory drug-binding protein antibody EXIP antibody MAP kinase 14 antibody MAP kinase MXI2 antibody MAP kinase p38 alpha antibody MAPK14 antibody MAX-interacting protein 2 antibody Mitogen-activated protein kinase 14 antibody Mitogen-activated protein kinase p38 alpha antibody Mxi2 antibody p38 antibody p38 MAP kinase antibody p38 mitogen activated protein kinase antibody p38alpha Exip antibody PRKM14 antibody PRKM15 antibody RK antibody SAPK2A antibody Stress-activated protein kinase 2a antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
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PMAPK14-140AP | |||
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PMAPK14-FITC | |||
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P-PMAPK14 | |||
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PMAPK14-BIOTIN | |||
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